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Clinical characteristics and prognosis of 35 patients with therapy-related hematological neoplasms However, despite these advances, a majority of patients are still dependent on modestly effective cytotoxic chemotherapy to provide disease control and prolonged survival. Novel distractors were associated with longer latencies and enhanced orienting responses (as measured by skin conductance responses) only when presented at an attended location. Experimental infections with the NC-1 strain of Neospora caninum were conducted in gerbils (Meriones unguiculatus) to determine their acute responses to experimental intraperitoneal infection. Subsequently, tip cells secrete the DER ligand Spitz and trigger local RTK signaling, which initiates morphogenetic movements resulting in the tip cell-directed invaginations within the SNS anlage.

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The distribution of the noradrenergic system within the rat cerebellar cortex following low-level X-irradiation was studied using tyrosine hydroxylase immunocytochemistry. Anti-anxiety drugs such as diazepam, nitrazepam, lorazepam, clotiazepam and etizolam produced marked elevation in the directed attack threshold dose-dependently.

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The insertion pathway of these proteins shares a common binding site with the general import pathway as the assembly of both Tom6 and Tom7 was competed by a matrix-destined precursor protein. Tsc2Ang1 cells demonstrate tumorigenesis in vivo and high-level expression of activated MAP kinase in vitro.

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With the recovered detector response as a base, the same model is applied in construction of the predicted in-flight field-of-view response of each GERB pixel to both short- and long-wave Earth radiance. We investigated whether the combination of genistein and zinc has additive and synergistic effects in osteoblastic cells in vitro. Approaches for the optimization of experimental parameters in capillary zone electrophoresis. Herein, we validated the biological activity of a Petiveria alliacea fraction using a metastatic breast adenocarcinoma model (4T1). Although repetitive postsynaptic firing asynchronous to the presynaptic activity results in a persistent synaptic suppression, the underlying molecular mechanism remains unknown.

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While two competitive proton-conductance mechanisms have been proposed, the actual proton-conductance mechanism remains an unsolved problem. The optic nerve of the brush-tailed possum, Trichosurus vulpecula: fibre diameter spectrum and conduction latency groups.

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Importance of the protection of the liver area in rats subject to a lethal dose of x-rays The prevalence and evolution of anemia associated with tuberculosis.

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We included every women at an HIV Unit of a hospital in Valencia who had been diagnosed of HIV infection at any moment between the first mother-child transmission reported in 1985 and 1993. Application of molecular modeling approaches has potential to contribute to rational drug design.

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The calculations required to evaluate the thermal environment can be tedious and time consuming. A response in the initial link produced a terminal link where a sequence of 10 key presses was reinforced with money. Currently, animal models are used to test the efficacy of tumor treatment. The models derived reproduced the high signal amplification through the cascade and the deviation of the cascade enzymes from the Michaelis-Menten kinetics, evidencing cooperativity effects. During exercise there is enhanced tumor perfusion and diminished tumor hypoxia due, in part, to a diminished vasoconstriction.

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Psychometric comparisons of trainees and consultants in anaesthesia and psychiatry. Relationships between adjustment to HIV and both social support and coping. These data suggest that consuming CM before competition has the potential to improve tennis match-play performance in masters tennis athletes.

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The reduction of NBD simultaneously initiated the polymerization of MMA. The right kidneys with hydronephrosis showed an echolucent dilated pelvis and overall parenchymal hypotrophy. Twenty-one anicteric patients with a t-tube in situ were studied between the ninth and 11th postoperative days. We utilized CRISPR/Cas9 to disrupt genes that are involved in NC formation in X. Early tapping of CSF by lumbar puncture or ventricular tap was suggested as a way of temporarily reducing pressure and removing blood and protein and thereby avoiding permanent hydrocephalus.

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They died on the 26th, 62nd and 105th day after virus inoculation, respectively. Dietary advice is equally effective when given by a dietitian, a practice nurse, or a diet leaflet alone but results in only a small reduction in total and low density lipoprotein cholesterol. Prophylaxis was started in 70 patients at a mean age of 4.1 years.

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Ultrasound strain imaging is a relatively low cost and portable modality for monitoring percutaneous thermal ablation of liver neoplasms. Proteinase cleaves the bait region of caprine inhibitor inducing major conformational changes and entrapping the enzyme within its molecular cage.

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Genotoxic sensitivity seems to vary during ontogenetic development. Negative correlation was found between monoclonal IgG and the most of the studied proteins inclusive immunoglobulins IgA, IgM and IgD. Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver. Receiver-operating characteristic curves for the best predictive model yielded an area under the curve of 0.82, indicating that standard risk factors were highly predictive of long-term outcome in young men. In efforts to obtain potential anticancer prodrugs for gene-directed enzyme prodrug therapy using Eschericia coli nitroreductase, a series of four benzocyclophosphamide analogues were designed and synthesized incorporating a strategically placed nitro group in a position para to the benzylic carbon for reductive activation.

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Orthogonal polarization spectral imaging of conjunctival microcirculation. A model for the interplay between PKA and gdt1 during the growth-differentiation-transition is discussed.

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The data demonstrate that Scn8a is required for the complex spiking of cerebellar Purkinje cells and for persistent sodium current in several classes of neurons, including some with pacemaker roles. Electroclinical characteristics of experimental epilepsy induced by electrostimulation Unlike classic quenching experiments, the crucial point in such studies is that the concentration of the quencher in the lipid phase differs from that in the bulk.

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Transfected mice expressed physiological plasma levels of human scFv and developed sustained ADAMTS13 inhibition and accumulation of unprocessed UL-VWF multimers. Data on the immunostimulating activity of polybacterial immunostimulants are presented. Therefore, we recommend avoiding routine US postoperatively and performing routine postoperative blood tests.

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Diffraction intensities measured while varying the D(2)O/H(2)O ratio in the humidity was used to solve the phase problem. Mechanistic information on the subcellular basis for the toxicity is frequently identified, including various mitochondrial effects, oxidative stress, calcium dyshomeostasis, phospholipidosis, apoptosis and antiproliferative effects, and a fingerprinting of the sequence and pattern of subcellular events. In occidental cultures the relation of humans to animals is determined by the human perception of the outer world. The recommended regime of treatment is summarised in the diagram in figure 7.

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Patients in the Kepi group had significantly lower VAS pain scores, longer TFA, and lower morphine consumption than patients in the Kiv or Ctr groups. Additionally, treatment with 0.1 mg/kg every second day but not with 0.01 mg/kg every second day of FK506 from the age of 12 weeks to 16 weeks induced regression of cardiac hypertrophy in DS rats. We collected information from 48 episodes of acute asthma over a 5-month period.

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A trained eye can spot strengths and weaknesses in a balance sheet with little difficulty and anyone who has a balance sheet prepared for them should at least have some basic knowledge of the implications. Stock A, with the highest ascites mortality, had lower values for BWG and FCR than stock B. After an adaptation night, polysomnography and Holter monitoring were done in the sleep laboratory.

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The emergence of model organisms with strong molecular genetic methodology in the other supergroups has recently facilitated a broader evolutionary approach to pressing biological questions. Immunohistochemical study on localization of deoxyribonuclease (DNase) in normal horny cells of the epidermis Stress was not reliably manifested in changes in heart-rate and breathing-rate. MicroRNAs represent a class of small RNAs derived from polymerase II controlled transcriptional regions. These findings provide significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression and also have implications for other genes regulated by Elf-1 and NF-kappa B family proteins.

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Zellballen pattern of paraganglioma on cytology is not a common finding and hence is being reported. The physiologic mechanisms involving growth factors, including PDGF-BB, EGF, and TGF-beta 1, as potent mediators of fibroblasts and epithelial cells in corneal wound healing remain unknown. The sensitive rate of imipenem, piperacillin/tazobactan was 100.0 percent, 44.5 percent, respectively.

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False moves for survival: error-prone DNA repair in adaptive immunity. Maximum-likelihood approach for gene family evolution under functional divergence.

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American Pharmaceutical Partners, a subsidiary of American BioScience, secured exclusive North American marketing and manufacturing rights to ABI 007 from American BioScience in November 2001. Antioxidative activity of sulfur-containing compounds in Allium species for human LDL oxidation in vitro. To further characterize the interaction of ERBP and erythropoietin (EPO) mRNA, we have examined the role of reduction-oxidation in the EPO mRNA binding mechanism of ERBP isolated from human hepatoma cells (Hep3B). Among several important contributing factors for stability of proteins are CG-rich codons, the ratio of charged amino acids compared to uncharged amino acids, ionic interactions, amino acid preferences and their distribution, post-translational modifications, and solute accumulation.

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Thirty cases of second toe-to-hand transfers are reported in which there were no failures. A simple screening test for estimation of some phenolic and indolic compounds in urine is described. However, even with an enhanced understanding of the relationship between GABAergic transmission and pain, it has proven difficult to exploit these findings in designing novel analgesics that can be employed for the routine management of pain. Locally delivered minocycline microspheres for the treatment of periodontitis in smokers.

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However, there are no clear-cut guidelines for the early diagnosis of GSF. The importance of de novo mutations for pediatric neurological disease--It is not all in utero or birth trauma. Five patients were operated for bilateral ectropium (lateral canthal sling procedure 4, Lazy-T 1), seven patients for dermatochalasis and one patient for brow ptosis.

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Successful intracytoplasmic sperm injection after failed in vitro fertilization due to multipronuclear oocytes. Some of the survey items were later updated through follow-up interviews and informal communications. Given this influence on CNS angiogenesis, we now investigated the involvement of microglia-resident NRP-1 in developmental retinal vascularization.

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In vivo demonstration of coronary thrombosis during the acute episode. Hyperandrogenaemia is a common feature of polycystic ovary syndrome (PCOS). Cardiovascular disease (CVD) remains a significant problem in Chronic Kidney Disease (CKD). Selective bladder filling prior to US should be performed in females when ovarian pathology is suspected. Pyrenophoric acid, a phytotoxic sesquiterpenoid penta-2,4-dienoic acid produced by a potential mycoherbicide, Pyrenophora semeniperda.

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This study presents the first application of a high-resolution magic angle spinning 1H NMR approach to elucidate the metabolic effects of a hypercholesterolemic condition and two high-fiber diets based on rye and wheat bread, respectively, in intact pig liver biopsy samples. Mosquito host choices on livestock amplifiers of Rift Valley fever virus in Kenya. Hydralazine does not inhibit canine hypoxic pulmonary vasoconstriction.

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Imaging findings in a patient with invasive thymoma in the costophrenic recess are presented, in whom computed tomography (CT) and MRI revealed lateral arcuate ligament thickening. One approach is to strengthen mechanisms for obtaining informed consent and for protecting confidentiality. Patterns of constitutive and IFN-gamma inducible expression of HLA class II molecules in human melanoma cell lines. Characteristics of benzo(a)pyrene metabolism and cytochrome P-450 heterogeneity in rat liver nuclear envelope and comparison to microsomal membrane.

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A phonoarteriogram was placed over the left brachial artery and the sphygmomanometer cuff was tied 2cm above the cubital fossa of the left arm. These findings demonstrate that lymphocytes express cyclin D1 and necessitate a reappraisal of the hypothesis that the D cyclins subsume redundant activities with tissue-specific expression. Its management is directed according to the integrity of the internal cervical os and patient hemodynamic status. Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs.

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The results showed that the presented pharmacokinetic-pharmacodynamic model was suitable for describing the antihypertensive interaction between telmisartan and hydrochlorothiazide. Stroke is one of the most frequent causes of death and disability worldwide leading to a significant clinical and socioeconomic burden. We observe that the wetting temperature rescaled by the bulk critical temperature decreases with an increase of the chain length. The chest radiogram and CT-scan showed displacement of the right kidney and most of the right colon into the thorax due to avulsion of the diaphragm from its dorsal insertion on the lumbocostal arch. The success of animal studies has led to interest in the clinical applicability of HCC immunotherapy.

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A complementary study showed that in mononuclear cells of patients who appeared to be sensitive to chemotherapy the decrease of antiapoptotic Bcl-2 protein expression and signs of apoptotic morphology were observed. Due to the failure to meet criteria for defining REMS, we conclude that neostigmine microinjection into the PRF of the mouse induces an abnormal waking state rather than REMS. Thus, we provide evidence that avidin functionalized MSNs (MSN-AVI) have the potential to serve as versatile biocompatible drug carriers for lung-specific drug delivery. Gene expression profiles were studied in 13 cases of salivary gland carcinoma including mucoepidermoid carcinoma (MEC), acinic cell carcinoma (ACC), and salivary duct carcinoma (SDC) using a cDNA array. This method performs well under low signal-to-noise ratio typically found in tomograms of vitrified samples under cryo-tomography conditions and can bridge gaps present on membranes.

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The role of the sickness funds in the Belgian health care market. Patients who had iodine-uptake-negative metastatic papillary or follicular thyroid cancers were selected from the thyroid database at The Royal Marsden Hospital and enrolled to an open-label, non-randomised phase II trial.

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2) The use of phenytoin and, to a lesser extent, phenobarbital and carbamazepine during cranial irradiation is associated with an increased risk for severe, potentially fatal, mucocutaneous reactions. MOAT partitions total survival time into clinically distinct periods that are operationally defined by cut points on established rating scales. Event-related potentials demonstrate deficits in acoustic segmentation in schizophrenia.