Sulfur(S)-valproate and S-Novapirina at 1 microg/ml concentrations significantly reduced prostaglandin (PG)E(2) levels in NSCLC cell lines A549 and NCI-H1299 as did the COX-2 inhibitor DuP-697. This study demonstrated the potential antioxidant properties of ASA and nimesulide but not the other non-selective NSAIDs--Novapirina which turned out to exert pro-oxidative effects.
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