This drug is used to treat high blood pressure. It is also used to lower the risk of strokes in patients with high blood pressure and an enlarged heart. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: Losartas and hydrochlorothiazide. Losartas is an angiotensin receptor blocker (ARB) and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used to treat heart failure.

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59Fe uptake method to differentiate between proliferation-dependent and nondependent cytotoxic agents. EphA4 and its ligand ephrinA3 are critical in the remodeling of neuronal dendrites and spines, but the relationship between ephrinA3/EphA4, stress-induced depression and antidepressants treatment is largely unknown. Seizure-like and interictal activity was evoked in rat horizontal hippocampal slices using a superfusing solution with low magnesium concentration (0.5-0.9 mm). Growing evidence suggests that for the sugar metabolism activators, multiple binding sites upstream of the promoter anchor the activator in a repressing or nonactivating configuration.

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Thus, total parathyroidectomy with autotransplantation of parathyroid tissue is a valuable method for restoring long-term parathyroid function in patients with secondary HPT and uraemia. Infusion of 12(S)-HETE and Ang II significantly decreased nephrin expression in LG, but increased it in SG compared to control. To establish a blood lead quantification correlation from two occupational health laboratories (OHL1V and OHL2DF), and the ABC Hospital (LABC) metals laboratory. Epilepsy surgery in pediatric intractable epilepsy with destructive encephalopathy. Dangerous (toxic) atmospheres in UK wood pellet and wood chip fuel storage.

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Information has been summarised which indicates that fish oil, obtained either as a dietary supplement or by the consumption of more fish products, represents a relatively simple and comparatively inexpensive dietary intervention which may lower BP, especially in combination with a low salt diet, and favourably alter multiple risk factors in the cluster. The impact of systematically screening for EDs in a primary care setting is not clarified and requires further investigation in collaborative cohort studies with a patient-centered approach, and outcomes focused on symptoms. Results As hypothesized, a negative association was found between free will perceptions and total symptom severity, though it appears that this was mainly accounted for by positive symptoms. Serum-free suspension large-scale transient transfection of CHO cells in WAVE bioreactors.

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Mass-spectrographic analysis of a porcine amelogenin identifies a single phosphorylated locus. This mode of resistance evolution may also apply to other drugs, and knowledge of the rates and mechanisms could be used to design improved diagnostics and by tracking the evolution of infectious strains, to inform the optimization of therapies.

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Identification of telomerase activity in gametocytes of Plasmodium falciparum. To explore the association between these white matter (WM) signal changes with early neurobehavior.

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The role of liver resection for hepatic metastases from noncolorectal carcinomas has yet to be clarified. The subsequent phenylthiazolinyl-S-PchE intermediate, arising from cyclodehydration of the N-benzoyl-Cys-S-PchE intermediate, is likewise a D,L-mixture on hydrolytic release and enantiomer analysis.

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In the in vitro study, cell proliferation and osteogenic differentiation was evaluated in the hBMSCs. The reduction of hemoglobins (Hb) M such as Hb M Iwate, Hb M Boston, Hb M Hyde Park, Hb M Saskatoon, and Hb M Milwaukee by the ferredoxin and ferredoxin-NADP reductase system was studied systematically under anaerobic conditions. Low back pain (LBP) is a problem that is frequently encountered in primary care, and current guidelines encourage care providers to take into account psychosocial risk factors in order to avoid transition from acute to chronic LBP. The postoperative pathological examination confirmed the diagnosis of ovarian serous papillary adenocarcinoma coexistent with peritoneal tuberculosis. Adrenaline produced an increase in systolic blood pressure, a decrease in diastolic blood pressure and an increase in heart rate.

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N-3 fatty acids, especially eicosapentaenoic acid (EPA), may possess anticachectic properties. Primary study on developmental speciality and cultural practices of Amphicarpaea edgeworthii

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Differing or increasing prevalence of positive allergen skin-prick tests observed in Europe could at least in part be explained by population changes in histamine skin reactivity. Dogs were randomly assigned to initially receive cosyntropin at 5 microg/kg or as a total dose of 250 microg, IV.

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Safety profile of proton pump inhibitors according to the spontaneous reports of suspected adverse reactions. This case shows new evidence for the presentation of extra luminal gastric gastrointestinal stromal tumour that are very rare and can mimic hepatic tumour. High survival rate of bovine oocytes matured in vitro following vitrification. Effects of diazepam, meprobamate, chlorpromazine and apomorphine on a quickly learned conditioned suppression in mice.

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In this scenario, the robustness of this flap was truly tested as it was raised from a previously irradiated site and did not have any issues of necrosis. Few patients brought to the ED on an involuntary hold required a medical screen.

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These two facts indicate that the SRCP conveys mainly messages about activity of the central spinal mechanisms, and that influences of supraspinal motor centers.on LRN neurons and on spinoreticular neurons are of minor importance. This was done by examining how effectively selected entry inhibitors blocked the infectivity of well characterized variants and molecular clones of the prototype isolate of FIV The results have shown that substitutions in the SU can indeed modulate virus susceptibility to TM-derived entry inhibitors.

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The latter develops into skeleton through endochondral ossification. Short-Chain Fatty Acids Regulate Cytokines and Th17/Treg Cells in Human Peripheral Blood Mononuclear Cells in vitro. Three risk factors appear to be specific or particular to the risk of SCD, and these and other risk factors operate differently in patients with versus those without preexisting IHD. The diameter of the tubules closely matches the curved shape of the N-BAR domain, which depends on the composition of the target membrane. 1 The anticholinoceptor action of 15 tricyclic antidepressants and derivatives has been studied on the guinea-pig ileum.

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Steady and pulsatile flow velocity measurements with a laser-Doppler anemometer (LDA) system indicate that the flow field downstream of the Abiomed valve is jetlike and turbulent. The role of lipopolysaccharide in toxicity of Francisella genus bacteria The findings were compared with those from eight trisomy-13 cases to determine whether or not the superficial similarities between the two syndromes were matched by similarities in the internal variations.

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Patients with hip OA with musculoskeletal comorbidities, such as low back pain and OA of the non-operated hip, have less long term functional improvement after THR. We also observe distinct cytoplasmic and nuclear immunostaining patterns under different fixation conditions in both normal and malignant epithelial cells, similar to those previously reported in the mouse reproductive tract. We hypothesized that the normal cellular DNA repair response in head and neck squamous cell carcinoma after radiation therapy can be blocked by a dominant negative disruption of the functioning MRN(95) protein complex. It is concluded that no safe method for directly viewing a solar eclipse is generally available, and that the public, especially schoolchildren and their children, should be better acquainted with this hazard.

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The tissue hypoxia and increase of oxygen active forms level worsen structural and functional status of erythrocyte membranes that led to the temporary anaemia. The role of pheromones and biostimulation in animal reproduction. Effective cardioprotection in clinical settings requires not only cardiomyocyte survival but also preservation of function. Past research suggests that Americans arm themselves when they do not trust one another. We studied the functional role of endogenous PHGPx in regulation of 12(S)-lipoxygenase and cyclooxygenase 1 activities in human epidermoid carcinoma A431 cells by using a cell system overexpressing anti-PHGPx mRNA.

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Teaching and the postdoctoral experience: impact on transition to faculty positions. Today the health service structure is well adapted to the needs of the country. In developing countries, relevant sources of indoor pollution include biomass and coal burning for cooking and heating. This study demonstrates that a hypoxic environment fully blocks COX-2 activity but favours iNOS gene expression in chondrocytes culture.

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This PR schedule may provide a useful method for evaluating the effects of pharmacological manipulations or lesions on opiate reinforcement. Analysis of pressure-sensitive film revealed significant increases in contact area and contact load at dorsiflexion in the joints between the distal phalanx and navicular bone and between the middle phalanx and navicular bone. Extramedullary hematopoiesis presented as a diffuse mass causing almost complete obliteration of the spinal subarachnoid space in a patient with known agnogenic myeloid metaplasia. Excluding coverage for male infertility places an undue burden on their female partners.

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A total of 50 individuals were studied (20 normals and 30 patients with hemiparesis). Participants were assessed in the areas of phonological awareness, verbal working memory, and rapid naming, in addition to oral language abilities as predictors of poor reading skills. The analysis with respect to various parameters arising out of fluid and geometry considered, on physiological parameters such as impedance and wall shear stress at the maximum height of the stenosis as well as across the entire length of the stenosis has been reported. Our algorithm can draw two types of conclusions not possible under previous methods: (1) that different assignments for an NOE would lead to different structural classes, or (2) that it is not necessary to uniquely assign an NOE, since it would have little impact on structural precision.

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Moreover, the GC activity was found to be lower in hamsters than in guinea pigs. Subsequent preclinical investigation has revealed several regulatory mechanisms, feedback pathways and unexpected enzymatic quirks in the MAPK pathway, which may explain this paradox. FTY720, a novel immunosuppressive agent with insulinotropic activity, prolongs graft survival in a mouse islet transplantation model. At a multicellular scale, comparisons were made with a Monte Carlo simulation in voxel geometry.

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Brain structures and neurotransmitters regulating aggression in cats: implications for human aggression. Monitoring of CD95 (APO-1/Fas) ligand expression in human T cells by quantitative RT-PCR.

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A cross-sectional survey in a large population randomly selected in 1992 with a 6-year mortality evaluation in Campania, a region in southern Italy. Wheat cytochrome P450 monooxygenase specifically catalyzes the metabolism of some sulfonylurea herbicides such as chlorsulfuron and triasulfuron. The authors describe some situations where meta-analyses would have been of great benefit if they have been done or sufficiently published. An 11-year-old cat presented for respiratory distress and weight loss. There is a growing body of evidence indicating an association between intoxication and major trauma.

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Options for the prevention and management of acute chemotherapy-induced nausea and vomiting in children. Regulation of dosage of conjugated equine estrogen is useful for add-back therapy. Disruption of TPLATE in Arabidopsis thaliana leads to the production of shriveled pollen unable to germinate. Traditional medications include intranasal corticosteroids, antihistamines, and immunotherapy.

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The mean time from CRPS diagnosis to (first) amputation was 5.2 years (sd 4.3) and the mean time from amputation to data collection was 6.6 years (sd 5.8). Measuring alcohol consumption and alcohol-related problems: comparison of responses from self-administered questionnaires and telephone interviews. Our results identify RingoA as an important activator of Cdk2 at meiotic telomeres, and provide genetic evidence for a physiological function of mammalian Cdk2 that is not dependent on cyclins. The roles of specific drugs and of drug interactions are reviewed.

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This paper presents the results of experiments using an in vitro model and an ex vivo animal model (Rana catesbeiana) to study magnetic particle retention in the conducting airways, specifically the trachea and bronchi. In vivo degradation of only those PGs with the subtypes A3alpha and A4alpha leads to the occurrence of large CW fragments, which persist in tissue and have good proinflammatory ability.

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Tackling the perceptions of health risk in young volunteers overseas. Our study thus highlights the importance of emotional dysregulation in adults suffering from ADHD, showing that they display higher emotional intensity than bipolar disorder subjects and controls. Biological and biomechanical evaluation of bone remodelling and implant stability after using an osteotome technique. We speculate that the relatively shorter cycle of the 50-g load may reflect an insufficient challenge to pancreatic function.

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However, several pitfalls, such as false positives, have been observed with PCR, underlining the necessity to interpret the results obtained with caution. These results strongly suggest that GSK3beta phosphorylates Sufu to positively regulate Hedgehog signaling in mammalian cells. Body weights among amygdalotomized grouped females were heavier (p is less than 0.05) than singly caged controls. These preliminary data indicate that cDNA clone tagging is useful for rapidly increasing the number and availability of genes in teleosts.

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The curves of peak response versus concentration were linear from 5.0 to 400.0 microg/L with regression coefficients of 0.9982, 0.9986 and 0.9976, respectively. Effects of diagnosis and treatment history on relapse of psychiatric patients.

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Characterization of heteromultimeric G protein-coupled inwardly rectifying potassium channels of the tunicate tadpole with a unique pore property. Comparative study of 2 prognostic classification systems for myeloma and examination of the correlation between initial bone marrow plasmacytosis and prognosis. Protective immune response of guinea pigs against challenge with foot and mouth disease virus by immunization with foliar extracts from transgenic tomato plants expressing the FMDV structural protein VP1

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Rocker shoes reduce Achilles tendon load in running and walking in patients with chronic Achilles tendinopathy. Infantile thiamine deficiency is a very rare condition in developed countries today. Finally, we propose some experiments suggested by the mathematical model.

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Structure of hepatic parenchyma was studied on histological sections stained with hematoxilin-eosine. Finally, it appears to be of equal importance to reach consensus on which histological areas are to be analysed.

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As indicated by numerous filipin-induced lesions, they were characterized by a high content of membrane cholesterol. Fibrillation is induced by placing a magnet over the implanted fibrillator. The study was to investigate the hemorheologyic changes of group A blood recipient transfused with large amounts of group O whole blood, by erythrocyte count, sympexis index, erythrocyte deformation index, erythrocyte rigid index and whole blood reduced viscosity, 60 ml of group A whole blood were added with 9, 12, 15 and 18 ml of group O whole blood (which corresponds to the 4 000 ml whole blood added with 600, 800, 1 000 and 1 200 ml whole blood). Comparative analysis of response to phenotypic and marker-assisted selection for multiple lateral branching in cucumber ( Cucumis sativus L.).

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Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment. Brief educational interventions may alter some stigmatizing negative attitudes toward mental illness in healthcare trainees in low- and middle-income countries. Three thousand and ninety-one preterm births and 5298 controls randomly selected from singleton births born at term during 1994-1997 were analysed.

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A striking feature of pulmonary infection with the Gram-negative intracellular bacterium Francisella tularensis, a category A biological threat agent, is an intense accumulation of inflammatory cells, particularly neutrophils and macrophages, at sites of bacterial replication. Since cells are believed to contain different receptors for each of the steroid hormones, it is not probable than the resistance of CF cells to these hormones results from a receptor deficiency. In the chronic phase after MI, IMR presence is associated with excess mortality independently of baseline characteristics and degree of ventricular dysfunction. The purpose of the study was to determine if polyamines, the metabolites of ornithine, and lysine have any diagnostic role in GA.

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Our data suggest that competition during processing and/or presentation between H2d-restricted peptides defines the immunodominant sequence of the viral protein. Immunoprecipitation and GST pull-down assays demonstrated that PRR7 binds to the third PDZ domain of PSD-95. Targeting pathways that centrally regulate both bone and muscle (eg, GH/IGF-1, sex steroids, etc.) and newly emerging pathways that might facilitate communication between these 2 tissues (eg, activin/myostatin) might allow a greater therapeutic benefit and/or previously unanticipated means by which to treat these frail patients and prevent fracture.

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The sensitivity to x-ray inactivation of cultured skin fibroblasts from clinically confirmed and suspected cases of ataxia telangiectasia was compared with that of cultures from normal subjects. Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer. Neither lactate accumulation in nor lactate release from muscle tissue can be used as evidence of anoxic tissue. Transcription-dependent nucleocytoplasmic distribution of hnRNP A1 protein in early mouse embryos. Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis.