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Glucagon (0.2 mg) caused an increase in left ventricular performance as evaluated by maximal dp/dt, time to peak ventricular pressure, and end diastolic pressure. We developed MrEnt, a Windows-based, user-friendly software that allows the production of complex, high-resolution, publication-quality phylogenetic trees in few steps, directly from the analysis output. Triphasic (arterial, portal venous, and delayed phases) dynamic CT was performed in 33 patients with 48 HCCs proven histopathologically and in 65 control subjects.

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A high percentage of our patients had avoidable causes of childhood blindness. The resulting AKAP9-BRAF fusion protein shows constitutive kinase activity, and it is able to transmit mitogenic signals to the MAPK pathways and to promote malignant transformation of NIH3T3 cells. Adult male Wistar rats were fed laboratory chow containing 1.0, 6.3, or 203 ppm benomyl, with control animals receiving standard laboratory chow. Using the virtual channel model, we present an intuitive analysis of the capacity of two-dimensional mobile networks and three-dimensional mobile networks, respectively.

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Difference in energy metabolism between fresh and warm ischemic canine pancreases during preservation by the two-layer method. Analysis of data-collection methods for an acute stroke care registry. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. This model is further investigated using two clinical trial designs. Naftidrofuryl treatment increases the length of the viable part of the skin flap in rats.

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Decrease in diastolic posterior wall velocity and rate of LV pressure change, and increase in LV end diastolic pressures also proved cardiac dysfunction. C2-C6 background hydrocarbon concentrations monitored at a roof top and green park site, in Dublin City centre. Spasmolytic action of histamine in airway smooth muscle of horse.

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It was found that not all batches of sodium rhodizonate were able to effect satisfactory visualisation of barium deposits. Therefore, VA cannot account for the shape of the torque-angle relationship on the plantar-flexor muscles. The use of the CAGE questionnaire in a cohort of homosexually active men. In vitro competition investigations showed that incubation of mouse zona-free eggs with a fixed concentration of recCRISP2 and increasing amounts of rat CRISP1 reduced the binding of recCRISP2 to the egg, suggesting that the proteins interact with common complementary sites on the egg surface. In the present study, the interaction between spermatogenic and somatic Sertoli cells was investigated in this culture system.

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While genuine pharmacological effects were considered as most relevant, pharmacists were highly aware of placebo and interpersonal factors. The authors conclude that Peutz-Jeghers syndrome with polyps in the duodenum can markedly distort duodenal and ductal anatomy and can lead to ampullary obstruction. However, in group-housed animals, (-)nicotine (0.025 mg kg(-1) s.c.) had a significant anxiolytic effect in the social interaction test, but 0.01, 0.05, 0.1, 0.25 and 0.45 mg kg(-1) were ineffective.

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The results suggest that ligand processing by endosomal proteinases is a key step in receptor signaling and function and a potential target for therapy. Bag1 is a regulator of heat shock protein 70 kDa (Hsp70/Hsc70) family proteins that interacts with steroid hormone receptors. Strangulated epigastric hernia in a 90-year-old man: Point-of-Care Ultrasound (POCUS) as a saving kit: Case report.

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Similarly, co-administration of zinc to chlorpyrifos intoxicated animals normalized the enzymatic activities of cytochrome P(450), NADPH cytochrome-c-reductase and NADH cytochrome-c-reductase within normal range. Blood gases, oxygen transfer, extracorporeal blood flows, priming volume, and setup times were determined. These findings suggest that a condition of oxidative stress occurs in patients with head trauma and hemorrhagic stroke of recent onset. To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Cestode parasites were also generally (15)N enriched with respect to mean host dietary signatures, but depleted with respect to host muscle tissue.

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In addition, they correct misperceptions of risk and facilitate knowledge transfer and translation. One mouse, two cultures: isolation and culture of adult neural stem cells from the two neurogenic zones of individual mice. Influence of oophorectomy on weight variance in young and adult female rats A Two-Year Ecological Study of Norway Rats (Rattus norvegicus) in a Brazilian Urban Slum.

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Although liposomes have received considerable attention with PEM coating for sustained drug release, similar results employing PEM built on poly(lactic-co-lycolic acid) (PLGA) particles is scant. The isolated feline iris was used as a key preparation, where prostanoid FP receptors and prostamide activity co-exist. Neuraminidase-1: a novel therapeutic target in multistage tumorigenesis. Pathologists were asked to indicate whether each phrase confirmed the disease, ruled it out, or was uncertain, together with a subjective estimate of how frequently they used the phrase.

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Antioxidant activity was measured by analysing the radical scavenging activity using a spectrophotometric decolorization assay and lipid peroxidation inhibition was assayed using liposomal model system with a fluorescence method. Assessment of p53, cyclin D1, p21 (WAF1), and Ki-67 (MIB1) at the ITF could help to predict local recurrence in early stage oral squamous cell carcinoma cases. It is discussed that the mechanism for the induction of radiation damage responsible for cytotoxicity may be slightly modified at ultrahigh dose-rates.

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The neutral position caused significantly lower compression of the median nerve than it did in the other positions. International perspectives on sexual harassment of college students: the sounds of silence. Ultrastructural comparison between skeletal muscle and cardiac rhabdomyomas.

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Collagen XVIII is a ubiquitous basement membrane (BM) component and a precursor of endostatin. Classroom-based approaches to developing social competence among hearing-impaired youth.

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Partial ileocaecocolic obstruction due to suspected enterolithiasis in a dog. Serum NSE and CA125 concentrations would provide valuable clinical information to assess disease severity in silicosis. A fundamental building block of RNA structure crucial to RNA function in diverse biological systems. A mutation in gene MPN142 (orf6) was identified in the Mycoplasma pneumoniae cytadherence mutant III-4. Our results demonstrate directly that NO may exert its neuronal effects through modification of protein cysteine thiols, and identify G(o) as a potential synaptic target of NO.

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The CT triad of extracranial soft-tissue tumour, underlying osteolysis and an intracranial tumour was reported as a sign of malignancy in meningioma, by Younis and Sawaya in 1992. Hirsutism scores, hormonal and metabolic profile as well as IL-6 levels were evaluated in each subject. Strikingly, ubiquitin-dependent proteolysis of alpha2 is required for two mechanistically distinct purposes: It allows the timely inactivation of one transcriptional repressor complex, and it prevents the de novo assembly of a different, inappropriate regulatory complex.

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Diisononyl phthalate (DINP) is a compound widely used as a plasticizer in the production of polyvinyl chloride products. There is very low quality evidence that calcitonin is no better than placebo or paracetamol regardless of mode of administration. Transthoracic Doppler echocardiography proved to be a clinically useful noninvasive method of assessing IMA graft function at rest and during exercise.

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Noncytotoxic inhibition of malignant cell growth by Ulex seed extracts. Our findings suggest that Chinese adolescents engaging both in NSSI and SA had severe suicidal attempts and were different from those who engaged in NSSI alone. The current 12 month point prevalence of wheeze has increased but this is confined to occasional symptoms. Cancer-related fatigue (CRF) is one of the most commonly reported and distressing symptoms experienced by adolescent and young adult (AYA) cancer survivors. The 15 questions included their preference for sweets, how many between-meal snacks they usually had per day, smoking and drinking habits, presence of oral symptoms, and attitudes towards dental visits.

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Of the test soils evaluated, ATS2015 and Edinburgh-M were found to be good choices for the simulated use of endoscopes, as their composition and viscosity most closely matched worst-case clinical material. Drug pricing is an example of a priority setting in a developing country with official requirements for the use of cost-effectiveness (CE) evidence. The control of these nematodes has relied largely on the use of a limited number of anthelmintics.

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Previous studies of an anal plug have yielded conflicting results. Moreover, a cluster of voxels in the orbitofrontal cortex showed a decrease in its activation that was specific to the particular liquid food consumed in a meal, providing a neural correlate of sensory-specific satiety to a liquid whole food in humans. Further analysis proved that the four compounds act as either microtubule polymerization inhibitors or histone deacetylase inhibitors.

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All patients in the limb-girdle muscular dystrophy 2B family showed apparent proximal dominant muscle atrophy and weakness, whereas a patient with Miyoshi myopathy in the second family showed distal muscle involvement at an early stage. This was suspected when specific electrocardiographic signs developed under digoxin treatment and disappeared either after discontinuation of digoxin alone, or in combination with specific treatment. Community involvement, local participation, must be developed as well as self-reliance. The effect of brief separation from companions on temperature was studied in 24-day-old chickens. Microvascular free tissue transfer for treatment of osteoradionecrosis of the maxilla.

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Changes in quality of life and work function during phase prophylactic lamotrigine treatment in bipolar patients: 6 month, prospective, observational study 560 penetrations were made on the medial and lateral banks of the middle suprasylvian sulcus (M.S.S.).

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The three-dimensional organisation of fibronectin (FN) in early amphibian embryos (Ambystoma mexicanum, Pleurodeles waltlii) was studied with the use of antibodies against amphibian-FN. A call for formal telemedicine training during stroke fellowship. The purpose of this experiment is to determine the effectiveness of both tetramers, used separately, compared with control.

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The 6MWT discriminates between disease severity, unlike the HFMSE. Similar addition of the 4-chloro, 6-chloro, N-methyl and O-methyl analogues 4, 6, 5 and 7 of the amino acid 1 reduced actamycin production and did not yield structurally modified ansamycins. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. Improvement in UE motor function on the FM was associated with a greater number of sites on the affected cerebral hemisphere where responses of the affected hand were evoked by TMS. If the subject changes the pressure pattern on his body by bracing himself in the rotating apparatus in different ways, it is possible for him to influence profoundly and systematically his apparent orientation.

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In this study, we aimed to identify the correlation between HVS on FLAIR and hypointense vessels on SWI, and to determine whether these imaging features provide independent prognostic information in patients with ischemic stroke. Empirical maps for the calculation of amide I vibrational spectra of proteins from classical molecular dynamics simulations. This phenomenon causes reduction in oxidative DNA damage, infarct size, and the extent of apoptotic cell death, leading to adaptation on functional recovery.

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This paper reports on the result of central bone chip bolting in the treatment of pseudarthrosis of the cuneonavicular joint, using an autologous bone chip according to the method evolved by Wilhelm and Sperling. In root and shoot apical meristems and during embryogenesis, cyc1At expression is almost exclusively confined to dividing cells. Economic disadvantage may adversely influence the outcomes of infants with gastroschisis (GS). c-Myc protein stability in mammalian cells is controlled by interdependent and sequential phosphorylation and dephosphorylation events on two highly conserved residues, serine 62 and threonine 58.

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Race-Based Health Disparities and the Digital Divide: Implications for Nursing Practice. We retrospectively studied 260 patients with post-traumatic elbow stiffness who underwent routine ulnar nerve transposition during open elbow arthrolysis.

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The methane absorption spectra within a range of 6080-6180 cm-1 were measured with a spectral resolution of 10 MHz and the signal to noise ratio more than 10(3). It has been shown that each pathological state was characterized by specific changes in the ultrastructure of Gall body complex, that pointed out its important role in the function of this type of lymphocytes and may be used as an additional cytological criterion in the estimation of T-immunity status. The clinical significance of slightly elevated serum human chorionic gonadotropin levels.

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Total body water decreased insignificantly with no change in extracellular body space on exposure to hypoxia. Proteolytically processed matrilin-4 species were also detected. Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration.

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All the subjects exhibited an increase of the surface density of mitochondrial cristae without changes of the outer membrane. Blocking calcium-dependent SK potassium channels converts the biphasic response into a prolonged depolarization. There were positive correlations between serum orexin levels and CTQ total score and between orexin levels and some CTQ subscale scores, such as physical and emotional neglect, in patients. Twenty-seven residents of a nursing home (NH) facility and 29 residents from independent living (IL) facilities wore ABP monitors for approximately 24-hours.

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The development of controlled-release nanoparticle (NP) technologies has great potential to further improve the therapeutic efficacy of RNA interference (RNAi), by prolonging the release of small interfering RNA (siRNA) for sustained, long-term gene silencing. Choline acetyltransferase activity is reduced in rat nucleus accumbens after unlimited access to self-administration of cocaine. Using a double-blind crossover Latin square design, the authors evaluated the peripheral anticholinergic and central nervous system effects of three dose levels of two tricyclic antidepressants in female volunteers. The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. As the next generation of scientists enters the field of environmental health, it is imperative that they view their contributions in the context of global environmental stewardship.

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Informative gene expression data and genomic classifiers that predict clinical outcome can be derived from prospective clinical trials of new anticancer agents. Sensory Stimulation-Based Complete Protection from Ischemic Stroke Remains Stable at 4 Months Post-Occlusion of MCA. Freeze fracture clearly demonstrates small gap junctions between neuronal processes in the neuropil, many of which are known to be electrotonically coupled. They were classified at 5-year intervals into 18 age groups, and each group consisted of 50-72 persons. The fate of thecal smooth muscle cells in postovulatory hamster follicles.

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The structure and physiological function of bHLH-PAS transcription factors Effect of cell size, age and anatomical location on the lipolytic response of adipocytes.

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Thanks to the documents found in the archives, and the testimony of their descendants, we were able to trace their biography. In contrast to the conventional direct integral equation approach that yields Fredholm integral equations of the first kind, the indirect integral equation approach yields well-posed Fredholm integral equations of the second kind. However, side-effect assessment comes up against several difficulties: distinguishing between somatic symptoms caused by the depression and those caused by the treatment -- which assessment tool to use (spontaneous notification, standardized scales that are not specific for the side effects caused by psychotropic drugs, standardised scales specific for the side effects caused by psychotropic drugs, meta-analysis, etc.) -- which data sources to consult (anecdotal reports, reviews, prospective studies), and which data set to use, etc. A negative correlation tended to be found between height and age in adult subjects, although this is thought to be a characteristic of Japanese, it may show the necessity of renewing regression models at intervals of 5 or 10 years.

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The optoacoustic system detects signals induced in the SSS and optoacoustic signals from the SSS linearly correlate with oxyhemoglobin saturation. Dramatyping: a generic algorithm for detecting reasonable temporal correlations between drug administration and lab value alterations. The warming-induced divergence of flowering and fruiting toward the two ends of the growing season resulted in a gap in the staggered progression of flowering and fruiting in the community during the middle of the season. All Tempofit FPDs, four Luxatemp FPDs, two Protemp Garant FPDs, and one Protemp 3 Garant FPD failed because of fracture during artificial aging. We can measure the effects of DNA methylation inhibitors, administered in vitro or in vivo, on the promoter methylation and protein expression of selected genes in specific cells.

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Antagonistic activity against four of the strains was observed, with a slightly higher threshold level than found for penicillin G, which was used in control experiments (Table 2). Measuring plasma lipids of all children in order to prevent atherosclerotic disease probably is not cost effective. The activation state of mTORC1, a master regulator of cell growth, is particularly sensitive to changes in the intracellular levels of the amino acid arginine, but the sensing mechanisms are poorly understood. The molecular defect has been elucidated in a number of inherited defects of thyroid hormone biosynthesis, secretion and utilization. This simple method shows the potential to control the shape, orientation and position of GO sheets over large areas.

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Chlamydial antigen EIAs are considerably less sensitive and specific, resulting in low positive predictive values, especially when low-prevalence populations are studied. Monthly ventilator-associated pneumonia rate time series summarized in a 51-point control chart showed the presence of special cause variability after intervention was implemented. This finding also suggests that except for the uncontrollability of worry, which was not measured by the PSWQ, there may be no difference in the process of pathological worrying between Ss with GAD and MDE. Then we analyzed the focus formation of phosphorylated histone H2AX protein, which is closely correlated with the induction of double-strand breaks. Patterns of genetic subdivision in parasite populations can provide important insights into transmission processes and complement information obtained using traditional epidemiological techniques.

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For strong enough flows, small-wavelength deformations like wrinkles are observed, similar to what happens in a suddenly reversed elongational flow. The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the anticancer activity in mice using DAL cell lines to induce cancer. Disappearance of the organism appears to correlate with the development of intestinal metaplasia.

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To evaluate stochastic and deterministic risks associated with neurointerventional procedures for the patient. To identify the optimal vehicle for fast and efficient cellular production of the photosensitizer, protoporphyrin IX (PpIX), upon administration of 5-aminolevulinic acid (ALA). In cooperation with the departments of maxillofacial surgery and orthopedics we used this technique to correct pubic diastasis and facilitate phallic reconstruction in a 4 1/2-year-old boy with bladder exstrophy who had previously undergone continent diversion.

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Taken together, these findings provide experimental evidence that dimethoate at subchronic oral doses has the propensity to impair glucose homeostasis, induce significant pancreatic damage and also provide an account of the associated oxidative damage to pancreatic tissue in adult rats. - Architectural expertise must be available within the health system, since very often outside consultants are unable or unwilling, because of the system of payment, to design suitable hospital buildings. Measurements were made to determine the critical stenosis and the results are similar to those reported from in vivo studies. In this study, we examined the effects of HGF on proteoglycan synthesis in interstitial fibroblasts, and the mechanisms of these effects. Acute lateral ankle sprain (ALAS) is a common injury, but its treatment has yet to be firmly established.