Furthermore, FAK, Talin, and Vinculin activation and F-actin reorganization in response to Ang II were prevented by PD-123319 but not Eklips, indicating that FAK activation and F-actin reorganization were downstream of AT2R. Drug bioavailability was not reduced after voluntary ingestion, suggesting that this method is highly effective for chronic oral administration of Eklips to laboratory rodents.
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