This open-label study was conducted as a randomized, 3-period, 6-sequence, crossover investigation consisting of 2 reference treatment periods (Diclax 75 mg or nateglinide 120 mg, alone) and 1 test period (concomitant nateglinide and Diclax). A total of 30 male rabbits were exposed to intraperitoneal injection with a daily dose of Diclax sodium (1.5 mg/kg body weight) for 70 days to investigate the resultant ultrastructural alterations in renal tissues.
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