Biger belongs to a group of medicines called statins.

It's used to lower cholesterol if you've been diagnosed with high blood cholesterol. It's also taken to prevent heart disease, including heart attacks and strokes. Your doctor may prescribe Biger if you have a family history of heart disease, or a long-term health condition such as type 1 or type 2 diabetes or rheumatoid arthritis.

This medicine is available on prescription only. It comes as tablets, including chewable tablets for people who have difficulty swallowing.

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By generating ALR knockdown cell lines and comparing their expression profiles to that of control cells, we identified a set of genes whose expression is activated by ALR. The purpose is to review the arguments for increasing use of existing data in health research. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.

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We calculated the changes in deoxynucleotide concentrations within the mitochondrion during the course of a mtDNA replication event and the time required for mtDNA replication in the different cell types. Activation of the intrarenal renin-angiotensin system, increased release of endothelin-1, dysregulation of nitric oxide (NO) and NO synthase, upregulation of transforming growth factor-beta1, inappropriate apoptosis, stimulation of inflammatory mediators, and enhanced immunogenecity have all been implicated in the pathogenesis of chronic CsA nephrotoxicity. Decreased expression of TGF-beta cell surface receptors during progression of human oral squamous cell carcinoma. Taken together, these findings suggest that sulfhydryl groups may play a role in vivo in the regulation of EPO production through the modulation of ERBP binding activity. A mathematical formulation for the proposed approach is reported and validity limitations are fully discussed, by demonstrating the ability to identify a great number of targets, up to 20, in the range direction.

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To investigate cardiovascular stress-reactivity in association with individual preconscious affective biases to threatening and appetitive facial stimuli. We investigated whether it is possible to apply a complementarity-based approach to evaluate the extent to which an existing network of restoration plantings meets representation targets.

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It produces larger amount of pollen, which has great potential for allergenicity in the pollination season. In this study, a mutant enzyme with a methoxy group in place of the hydroxy group of Thr-252 (OMe-mutant) was synthesized by the method of unnatural amino acid mutagenesis (Noren, C. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Membranous cellular degradation products upon various tissue injuries apparently serve as nidi of calcium apatite nucleation. Microbial genome sequencing has entered a new phase, where DNA sequence information is gathered from entire microbial communities (metagenomics or environmental genomics) rather than from individual microorganisms.

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We have previously shown that CREB-binding protein (CBP/p300) act as an important SOX9 co-activator during chondrogenesis. atherosclerotic and arteritis patients: atherosclerotic or inflammatory lesions?

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The endoscopic (and histopathologic if necessary) diagnosis was collected after the procedure. The survey of British laboratories in 1970-74 was continued by a questionnaire to members of the Association of Clinical Pathologists covering the next two years.

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However, body-condition decreased with density in natural nests, but increased in experimental nests. Current international legal instruments recognise the use of advance directives to carry on the will of the dementing research participant beyond the boundaries of her present legal capacity. Subjects receiving nicotine exhibited a significantly lower temperature response as well as attenuated cardiovascular responses for 2.5-6 h after LPS exposure.

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IBD patients lack immature blood DC during flare ups which possibly migrate to the gut. To derive a more precise estimation of the relationship, a meta-analysis was performed. Further efforts are needed to implement smoking cessation advice and support in clinical practice. Electromyographic activity data of denture/overdenture subjects revealed no differences between prostheses worn versus not worn during sleep but demonstrated a very large variance factor.

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Case of common variable hypogammaglobulinemia associated with gastric carcinoma It could be conserved by tissue gluing with highly concentrated human fibrinogen. Literature on chemical restraint and use of tiletamine and zolazepam in rheas is scarce. Infections after tooth extraction and fracture of the sclerotic bone following mild trauma are serious complications, as these ordinarily common problems are very difficult to treat in such patients. However, confidence varied considerably depending on clinical context.

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The amount of needle elongation growth was highest for mature trees and amount of branch elongation growth was highest for saplings. This study identified several potentially modifiable factors that may be useful for preventing suicide in people with MS.

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Etiology, pathogenesis and clinic-diagnostic aspects of hepatic abscess A multidrug resistance transporter in Magnaporthe is required for host penetration and for survival during oxidative stress. In addition, 2-aminopurine (2AP) binding studies have been used to test the consensus sequence derived from the alignment. In addition to routine demographics, each case was reviewed for presenting symptoms, site of obstruction, and type of surgical treatment. These results suggest that, although better control may reduce the incidence of coronary artery disease in Type 1 diabetes, a residual risk related to the haptoglobin 2 allele remains.

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The host strain is auxotrophic for phenylalanine, tyrosine and tryptophan. SPECT counts were obtained by the ROI method from each images to calculate relative CBF from rest to 7.5 and 20 minutes after ACZ administration. Participants in the workshop discussed efforts to improve mobile source emission models and emission inventories, results from gas- and particle-phase emissions studies from spark-ignition and diesel-powered vehicles, new methods for measuring mobile source emissions, improvements in vehicle emission control systems (ECSs), and evaluation of motor vehicle inspection/maintenance (I/M) programs, as well as topics for future research. The most dependable factor to perform successful biochemical experiments in an O2-free environment is the experience required to set up an efficient laboratory, to properly manipulate samples, to anticipate potential O2-related problems, and to maintain the complex laboratory setup operative. To describe bone status in children with Alagille syndrome (AGS) and healthy control children adjusted for age, gender and height (HT), and to identify dietary intake and AGS-related factors associated with bone status.

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The results of this study suggest that treating asymptomatic bacterial vaginosis does neither markedly prolong pregnancy nor increase birthweight. The real time caliper system may be calibrated to 1540 or 1600 ms-1 using markers thus displayed on the real time machine.

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We provide evidence showing that both Tax and p73 interact strongly with the C/H1 domain of CBP and that their binding to this region is mutually exclusive in vitro. Organ donation and transplantation in the Kingdom of Saudi Arabia 2005.

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Circular RNA of cattle casein genes are highly expressed in bovine mammary gland. A more than fivefold increase in the hydrolysis of aspirin was noted when the temperature was raised to 37 degrees from 22.5 degrees. Main emphasis is made on heart rhythm disturbances in this disease.

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Radiological aspects of the wrist and hand in chronic polyarthritis in the adult and in ankylosing spondylarthritis Effectiveness of psychotherapy in current practice in psychiatric consultation This space can also provide a protective mucosal barrier accommodating interventions into the deep layers of the gut wall and body cavities, such as the abdomen and mediastinum. In 42 patients with a spinal cord lesion and chronic urinary tract infection the bladder wash-out test was performed to locate the site of infection.

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However, this topic has received little attention in the nurse practitioner literature. This review discusses the value of LANCL2 as a novel therapeutic target for the discovery and development of new classes of orally active drugs against chronic metabolic, immune-mediated and infectious diseases. The currently accepted approaches to treatment of pulmonary fibrosis are based on the treatment of alveolitis and pulmonary fibrosis, however clinically available anti-inflammatory and antifibrotic agents are not often beneficial. The best method seems to consist of the use of McCoy cells treated with cytochalasin B for routine isolation and of acridine orange for the staining of inclusions. Zebrafish (Danio rerio) is a very powerful animal model which has shown to present the same cartilage phenotype that is commonly seen in mice model and patients with the rare hereditary syndrome, Multiple Osteochondroma (MO).

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TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer. Identifying Patients with Bacteremia in Community-Hospital Emergency Rooms: A Retrospective Cohort Study. Mapping of the Src-catalyzed tyrosine in vitro and in vivo by site-directed mutagenesis demonstrated Tyr(477) as the primary target residue.

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Rational combinations of antihypertensive drugs depending on the specific clinical situation are marked. The method can simultaneously detect two different loci of Vibrio cholerae in a single reaction. MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer. Patients who received counselling were more likely to have improved psychological symptom levels than those who did not receive counselling. Improved stereoselectivity in dehydrogenase-mediated reductions has been achieved by rationally designed gene overexpression and knockouts in Saccharomyces cerevisiae cells and by isolating and characterizing novel dehydrogenases from other organisms.

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Yet, little data exists on the prevalence or magnitude of these risks in the current context of shale gas development. Patients with recurrent breast disease presenting to the Breast Unit of Liaquat National Hospital and Medical College, Karachi, between January 2004 and January 2011 were included in this study. The principle used to estimate the doubling time of the circulating parasites was the decrease in specific activity of 10(-7) parasites and this was determined both for parasites contained in a whole blood sample and for parasites separated from the blood sample by DEAE-cellulose chromatography. Analysis of ventricular shape by echocardiography in normal fetuses, newborns, and infants. In the control animals, it was observed that a progressive reduction in DPOAE level followed each successive IAA compression at all three test frequencies.

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From January 1987 to March 1999, 14 patients underwent curative resection for liver metastases from noncolorectal carcinomas. Proximal row carpectomy and four-corner fusion are commonly used in the patients with scaphoid nonunion advanced collapse or scapholunate advanced collapse.

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Comprehensive hygienic evaluation of the environmental protection problems of modern industrial territorial complexes It consists of purified LS from bovine sources and retains the surfactant proteins (SP) SP-B and SP-C, both thought to be important in proper respiratory function. Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a heterogeneous group of birth defects with a variety of genetic and nongenetic factors suspected of involvement in the etiology.

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This work demonstrates that by using proper and rigorous techniques, it is possible to correctly model polypeptide dynamics in solution with a spherical cutoff. DNA damage and its resolution were studied by observing the kinetics of gamma-H2AX foci formation and by comet assay analysis. In this experimental study, Donor MSCs were isolated from bone marrow of Wistar rats.

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Here, we show that low-level stimulation of the primate frontal eye fields can induce robust pupil dilation without saccades. Clinical and angiographic variables affecting the progression of coronary artery disease as determined by quantitative angiography. Overexpression of eIF5A2 was found in cancerous tissues compared with adjacent tissues.

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The prevalence and significance of antiorganelle antibodies in the serum of patients with chronic hepatitis C is a subject of controversy. Genetic ablation of Sepp-expression causes a drastic decline in serum (25-fold) but only a mild reduction in bone (2.5-fold) Se concentrations. The brain zonisamide concentration and the concentration ratio of brain/serum at 2 h after administration of zonisamide (50 mg/kg) were significantly higher in stressed group, rather than that in the nonstressed control group without changing the serum concentration. The results turned out that hydrogen peroxide production started at the beginning of logarithmic phase, and reached the maximal yield at the early stationary phase.

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Relationship between travoprost and central corneal thickness in ocular hypertension and open-angle glaucoma. Trial selection, data extraction and quality assessment were carried out independently by two reviewers, and confirmed with corresponding authors. To determine the incidence and severity of symptoms related to the diagnosis of post-traumatic stress disorder (PTSD) in a cohort of general ICU patients.

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A total of 25,600 EMS encounter forms were reviewed, yielding 2,399 patients with a potential cardiac syndrome. The third period (2005-2012) represents the first attempts at health reform and recovery, linked to emerging trends in national political reform and international politics. Although the targeted deletion of PUMA did not affect ER stress, mitochondrial apoptotic signaling was downregulated in mice. The results obtained in this case study showed that the application of ordinary kriging to both ICP-AES and transformed PXRF analysis data is the most accurate approach when considers the spatial distribution of copper and lead contaminants in the soil and the estimation errors at 11 sampling points for validation.

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Is papillectomy in cancer of the duodenal papilla a radical surgery? In the opposite case, when this reaction becomes essentially hopping, the corresponding rate is significantly accelerated due to a faster diffusion of the free electron. In summary, we identify Neogenin as a pivotal component of the AJ, where it influences both cadherin dynamics and junctional tension. Collagen-I deposits in the affected lungs were detected by Sirius red staining of paraffin embedded lung sections. In addition, Tochigi, Kochi, and Nagasaki showed standardized mortality rates higher than 1.5 without significance.

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Plasma lactate and free fatty acids levels in fed bats were higher than in other mammals, although no changes in these levels were detected in response to fasting. Although three large phase III trials have documented the benefit of IP chemotherapy, this therapy as consolidation has been studied in only a few pilot studies. Many reproducible and valuable measurements were possible, the accuracy of several was increased, and new measurements were defined. Conversion to total cavopulmonary connection was carried out concomitantly with surgical intervention for atrial arrhythmia in 4 patients undergoing the Fontan procedure by atriopulmonary connection and having continual atrial fibrillation or flutter in the longer term after the initial procedure. The two ways seemed far away from each other: Delta-gamma-1 influenced both the nuclear and cytoplasmic functions of the cell.

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Despite these divergent responses with respect to senescence, cell death, metabolism, and gene expression, the signaling events in both systems are mediated by the generation of mitochondrial-derived reactive oxygen species (ROS). A number of variables that may affect the seizure threshold during ECT were examined. Larvae that had experienced a prolonged delay had reduced survival rate, metamorphosis success, and juvenile survival, but among older larvae, Em had the highest success followed by Ea, Eo, and Ec.

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These methods can be used in combination, and in continuous scan mode for rapid data acquisition when using multiple probe mode reconstruction methods. BDNF enhances retinal ganglion cell survival in cats with optic nerve damage.

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There were three areas of experimental inquiry: (1) How reproducible are the various clinical means by which torque is applied to the fastening screws, both in absolute and relative value? However, whether this neuropeptide also alters levels of 2-arachidonoyl glycerol (2-AG), the most abundant endocannabinoid in the CNS, in astrocytes remains unknown. Oil Red O staining revealed that PPARgamma2 induces lipid accumulation in hepatocytes.

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FHIT and proliferating cell nuclear antigen (PCNA) expression were detected by immunohistochemistry, and apoptotic level was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay on the tissue sections. Uterine rupture represents indication for immediate cesarean section and it should be performed within 25 minutes of the first signs of uterine rupture.

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Zone 3 contained gold particles only in the epidermis and had necrosis of only a few scattered cells. Cell patterning on photolithographically defined parylene-C: SiO2 substrates. Training, practice, and referral patterns in hepatobiliary and pancreatic surgery: survey of general surgeons. In an exploratory study, 11 common polymorphisms were examined for contributing to longevity including: apolipoprotein E (apoE), methylenetetrahydrofolate reductase (MTHFR), cathepsin D (CAD), superoxide dismutase 2 (SOD2), angiotensinogen (AGT) and insulin-like growth factor 2 (IGF2), Leiden factor 7, p53 oncogene, dopamine D4 receptor (DRD4) and the serotonin transporter (SERT). It is probable that many animal taxa will possess attributes amenable to bioremediation.

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This linear NADH oxidation was directly proportional to enzyme concentration in the assay mixture until changes in absorbance of 0.12 per minute. Inappropriateness of randomised trials for complex phenomena: are the results of the term breech trial generalisable? The effect of coenzyme Q10 and vitamin E on the regeneration of skeletal muscles in pigs. One-on-one survey interviews were completed with 201 Hmong women aged 20 years and older in Fresno, Long Beach, Orange County, and San Diego to determine their breast cancer screening behaviors--breast self-examination (BSE), clinical breast examination (CBE), and mammography.