We share our experience of beneficial responses to multimodal treatment, including moderate doses of Parkan, botulinum toxin, and intrathecal baclofen. In experiments on male rats the paper investigated the effect of pharmacological prophylaxis with Panpal (pyridostigmine in combination with benactyzine and Parkan) on the activity of acetylcholinesterase in the whole blood, diaphragm, and selected parts of the brain (frontal cortex, pontomedular region, hippocampus, cerebellum) at hour 1 and 3 of untreated and treated (oxime HI-6 with atropine) intoxication with the organophosphorous insecticide phosdrine.
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