Antabuse, a drug used in the treatment of alcohol dependence, is an inhibitor of dopamine-β-hydroxylase causing an increase in the concentration of dopamine in the mesolimbic system. In addition to the physical symptoms associated with concomitant use of alcohol, Antabuse may lead to adverse events, when used alone, including psychosis. Aims. To report a case of a rare complication when using Antabuse for alcoholism treatment in a patient in alcoholic abstinence. Case Report. We describe the case of a 42-year-old male patient, who developed psychotic symptoms 3 weeks after initiating treatment with Antabuse for alcohol dependency. The patient had a history of chronic alcoholism for 12 years and was under Antabuse treatment (250 mg/day) for 1 month, with no other past history of psychiatric illness. The symptoms worsened after he initiated alcohol consumption, while taking Antabuse. The patient was hospitalized and Antabuse was suspended. After 4 days he was asymptomatic and at 6-week follow-up remained asymptomatic.
Other names for this medication:
Disulfiram,
Antabuse,
Anticol,
Aversan,
Esperal,
Etabus,
Tenutex,
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