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Actalipid (Simvastatin)
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Simvastatin

Liquid chromatography-tandem mass spectrometry assay for the simultaneous quantification of Actalipid, lovastatin, atorvastatin, and their major metabolites in human plasma. Actalipid also killed primary CD34 cells from patients with CML more efficiently, compared with CD34 CML cells.

Other names for this medication:
Simvastatin, Zocor, Actalipid, Lipex, Lipinorm, Lodales, Simcard, Simgal, Simvastatina, Simvor, Sinvacor, Sivastin, Vasilip, Zeid, Zocord, Zosta, Zostin,

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Actalipid is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Actalipid is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood. Actalipid may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Actalipid is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Actalipid has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

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Maximal enhancement of microsomal nitro reductase activity by haemoglobin is achieved at high substrate concentration (6 mM) and low microsomal protein concentration (0.5--1.0 mg/ml). She had prognathic maxilla, retrognathic mandible, and full cusp Class II molar and canine relation bilaterally with overjet of 7 mm.

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Treatment with dimethylsulfoxide (DMSO) for 24 h almost completely inhibited labeling of sulfated proteins, and up to 48 h, labeling was found almost entirely in a band at 125 kDa. Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells. Attenuation of FGF-signaling is accompanied by the induction of Sprouty-2 phosphorylation on the amino-terminal as well as carboxyl-terminal tyrosine residues, which are less effectively modified upon EGF treatment. Speciation and intrasubspecific variation of Bornean orangutans, Pongo pygmaeus pygmaeus.

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Our field is evolving from a largely research oriented science to a service-oriented specialty. The data indicate strong links between physical inactivity and obesity. To determine the oral status of elderly residents in nursing homes (NH) and long term care wards (LT) and to describe associations between oral status and nutritional status among institutionalized elderly residents. In this study we investigated the effects of the LXR agonist T0901317 and the RXR agonist 9-cis-retinoic acid (9cRA) on cell proliferation and apoptosis in MIN6 cells. Additionally, E-cadherin and keratin were downregulated while N-cadherin and vimentin were upregulated in EECs.

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Polarization begins in the unovulated oocyte and is reinforced at fertilization. Effect of myringotomy on gastrointestinal disorders in infant in the absence of otitis Hypertrophic osteoarthropathy: an unusual manifestation in nasopharyngeal cancer. Basicranial features were examined in catarrhine primates and early hominids in order to demonstrate how information about morphological integration can be incorporated into phylogenetic analysis. Resolution of some of these issues was attempted by analyzing the pathologic features of 573 examples of DCIS obtained from a larger cohort of 790 women with DCIS enrolled in Protocol B-17 of the National Surgical Adjuvant Breast Project.

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A comparison of behaviour following stimulation of the anterior substantia nigra by direct cholinergic agonists and anticholinesterases. We studied 80 patients with untreated chronic hepatitis C to determine whether steatosis contributes to fibrosis through a steatohepatitis-like pathway. It was concluded that the question format and focus must be structured to the ICF in the survey development phase in order to achieve the best possible base for international comparability. Several measures of the dynamic response were computed but the most representative was the maximum rate during cooling or the minimum rate during warming.

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There was found to be a clear relationship between (a) the location and size of the infarcts and (b) the presence or absence of wallerian degeneration. COMPARATIVE STUDY BETWEEN THE PUBIS OF ASYMPTOMATIC ATHLETES AND NON-ATHLETES WITH MRI. We hypothesized that CAD negatively impacts renal functional outcomes among patients with ARVD undergoing renal artery revascularization. In a second phase, a sub-sample of 100 children was selected for more detailed diagnostic assessments.

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L-5418 has an anti-convulsant effect which is similar to that of diphenylhydantoin. Interestingly, in postnatal KDelta75 mice, we observed a dramatic reduction in microglial cell numbers similar to in vitro microglial cell differentiation impairment. The objective of the study described here was to analyze in rainbow trout (Oncorhynchus mykiss) the effects of low protein intake on peripheral glucose phosphorylation capacities and gluconeogenic enzymes in kidney and intestine. The affected sisters exhibited vertical ridges on the enamel surfaces, whereas the affected father had thin, smooth, yellowish enamel with distinct widening of inter-dental spaces.

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Integrating a state water pollution control program with a regional water resources plan. In 20 patients referred for renal angiography, series were obtained, 30 s., 3 and 10 min. Loss of tolerance is considered to be an early event that is essential for the development of autoimmune disease. We have found a ratio of full-length wild-type to mutant protein in plasma HDL of three to one.

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The current Paediatric Life Support (PLS) Guidelines 2015 of the European Resuscitation Council (ERC) acknowledge both limited scientific evidence and aspects of practicability. SEAWEED EXTRACTS AS A POTENTIAL TOOL FOR THE ATTENUATION OF OXIDATIVE DAMAGE IN OBESITY-RELATED PATHOLOGIES1. Frequency of nerve population increased from apex to base of the heart. The BQ-788-elicited deterioration of reoxygenation-elicited changes was attenuated by NO supplement with S-nitroso-N-acetyl penicillamine. The development and application of a post-column detection system for K vitamins based on their photoreduction to the hydroquinone form is reported.

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Identification of a common variant in the lipoprotein lipase gene in a large Utah kindred ascertained for coronary heart disease: the -93G/D9N variant predisposes to low HDL-C/high triglycerides. Site-selective lateral multilayer assembly of bienzyme with polyelectrolyte on ITO electrode based on electric field-induced directly layer-by-layer deposition.

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A key regulator of synaptic plasticity is a signaling pathway that includes the mitogen activated protein (MAP) kinase. Using specific antibodies against each of the binding proteins, we identified both HB1 and HB2 in several other tissues (intestine, lung, kidney, ovary ...) and further, revealed relative differences in the expression of HB1 and HB2 between various tissues. Also in the autopsy cohort, C4d immunohistochemistry demonstrated unexpected membranous nephropathy in two patients, yet C4d also colocalized with arteriolar hyaline. Transcriptional kinetics of structural genes were monitored by Northern blot analysis in a 60-min time frame after cells were exposed to an N oxide signal.

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Patients particularly at risk are identified and the causes of PEM are outlined. Ortho effects in quantitative structure-activity relationships for acetylcholinesterase inhibition by aryl carbamates. Studies on the placental transfer and distribution of 3H-PGF2alpha in rats on day 14 of gestation revealed that the isotope and/or its metabolites readily crossed the placenta.

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However, transmission was heterogeneous with hotspots of prevalence and/or seroprevalence detected in both highland and highland fringe altitudes, including a serological hotspot at 2,200 m. Metabolic inhibition of meloxicam by specific CYP2C9 inhibitors in Cunninghamella blakesleeana NCIM 687: in silico and in vitro studies. The HCV infection of a fourth HCV RNA-positive donor could not be identified by routine, second-generation HCV EIA (Abbott Diagnostika).

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Thus, we provide a systematic and comprehensive classification of different movement similarity measures used in geographic information science. We confirm the feasibility of minimal-access arytenoid adduction and abduction through development of a new technique and device.

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Telemetering of intrauterine pressure is an advantageous method. These genetic variations were found in both affected and nonaffected individuals, and there was no correlation between gene variants and the phenotype for adolescent idiopathic scoliosis. Intermittent hypoxia induces plasticity in neural networks controlling breathing and cardiovascular function. Droplets on leaves inclined at high angles can be completely removed from the surface by self-propulsion with the assistance of gravity. Thus, the long-term costs of inbreeding due to lower male reproductive success we have shown in another study appear to be unrelated to inbreeding depression for adult male size or the growth rates that are reported in the current study.

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It is suggested that both acute and subclinical bleeding from such tumors may sometimes underlie the development of raised intracranial pressure occasionally encountered. Peripheral administration of GA was found to augment neurogenesis, including cell proliferation, migration, and differentiation in rodent brain. The authors studied clinical, roentgenologic and functional signs of asbestosis and chronic dust bronchitis in 57 workers engaged into extraction and processing of asbestos. This makes Ln(III) and Ce(IV) ions attractive candidates for developing selective and efficient artificial nucleases, which could have many biochemical and clinical applications. We hypothesized that transvascular lipoprotein transport may be increased in patients with diabetes, possibly explaining increased intimal lipoprotein accumulation and thus atherosclerosis.

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Proliferative effects of flavan-3-ols and propelargonidins from rhizomes of Drynaria fortunei on MCF-7 and osteoblastic cells. Gelled depsipeptides degraded at a slower rate than non-gelled samples in the presence of salt, while hydrolysis in water of both gels and solution samples was minimal even after 14 days. The rate of postoperative complications for transplantation from a living kidney donor is lower than that for postmortem kidney transplantation. The AFP-producing but not AFP-nonproducing HCC cell lines that were transfected with the MK promoter-linked herpes simplex virus-thymidine kinase (HSV-TK) gene became susceptible to a prodrug ganciclovir to a similar degree of the HCC transfected with the enhancer-linked AFP promoter-fused HSV-TK gene. Mey, together with eight known analogs, ginsenoside-Rb(1), -Rb(2), -Rc, -Rd, -Re, -Rg(1), -Rh(1), -Rh(2).

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Specifically, CD40L was associated to the surface of cells that were detaching and migrating from the monolayer of ECs, whereas for CD40 a very diffuse subcellular localization was seen at the monolayer and the detaching and migrating cells. To best address the many clinical issues related to the safe and effective care of the postbariatric patient, the authors have established a dedicated multidisciplinary treatment center.

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The uroporphyrinogen-I-synthetase (UIS) activity in red blood cells was determined in 206 individuals from 48 nuclear families ascertained through a proband with acute intermittent porphyria (AIP) as well as in 230 members belonging to 53 nuclear families with no signs of AIP. Researcher and researched--community perspectives: toward bridging the gap. They are also involved in tissue remodeling via cytokine secretion and apoptotic body clearance. Findings attempting to differentiate between the two systems in normal subjects have been controversial, with some researchers arguing that there is a single memory system and only the match in processes used during learning and later at retrieval can be important.

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Clinical aspects and radiosensitivity of bone metastases in kidney neoplasms Additionally, this product was recently approved by the FDA for the treatment of anemia in patients with nonmyeloid malignancies where anemia is due to the effect of concomitantly administered chemotherapy. When compared to parental organisms of the inoculum, ex-vivo pneumococci with mutant alleles of the F0/F1 ATPase had acquired the capacity to grow at low pH at the cost of the capacity to grow at high pH. For these reasons, CFF is used as a cognitive indicator in drug studies, as a measure of fatigue, and has been suggested as a diagnostic measure for various brain diseases.

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A child with a de novo interstitial deletion, 46,XX,del(2)(q31q33), is described. In this study, we aimed to clarify the trends of adjuvant therapy for intermediate/high-risk cervical cancer after radical surgery in Japan. The women most likely to bedshare are non-white, single, breastfeeding and low-income. Seven dairy-goat farms, located in central, western France, were studied in order to assess the variability in susceptibility of the lungworm Muellerius capillaris first-stage larvae (L1) to 3 different anthelmintics in relation to farm origin, by means of motility tests. The purpose of this article is to describe the segments, and the screening instrument, and to present initial tests of its validity.

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Surgical treatment without hospitalization of senile cataract in Senegal Decreased carnitine uptake in cultured cells from a woman with endogenous obesity. We calculate the statistical properties and the average gray value of pathological images and then update the current pixel value as the absolute value of the difference between the current pixel gray value and the average gray value, which can be more sensitive to the gray value changes of pathological images. In classic albinism, all parts of the body are normal except for the absence of melanin.

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Even if not all of the fragments are in the database, the elucidator proposes relevant substructures that can help chemists to identify the actual chemical structures. Collectively, we have identified a novel signaling pathway, involving MAVS-MKK7-JNK2, which mediates virus-induced apoptosis and highlights the indispensable role of mitochondrial outer membrane in host defenses. Long-term anticonvulsant prophylaxis is usually not indicated when drug intoxication or withdrawal is the sole cause of a seizure.

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Chronic persisting hepatitis and the attempt at immunostimulation These facts indicate that the hypodiploid cells mostly arose as technical artefacts during slide preparation but that hyperdiploid cells were mainly due to non-disjunctional gain. The size of tumor volumes became significantly smaller than that of controls. The antiretroviral rollout and drug-resistant HIV in Africa: insights from empirical data and theoretical models.

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Ancylostoma caninum: The finger cell neurons mediate thermotactic behavior by infective larvae of the dog hookworm. Our data also indicate that hsp90 and p23 remain associated with functional telomerase complexes, which differs from other hsp90-folded enzymes that require only a transient hsp90.p23 binding. In this review, we discuss the history and summarize current knowledge regarding BCL2 inhibition as therapy of CLL. The recommendation is made that the high levels of supersaturation generally used for the decompression of men be reduced. Height, weight and waist circumference were measured in all subjects.

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Neutrophil to lymphocyte ratio(NLR) is an independent predictor of acute coronary syndrome. Two days later, subjects were asked to freely recall the gist of all of these events, and they did so while simulating a mood that either did or did not match the one they had feigned before. She had no symptoms but chest X-ray film showed a single nodule in the right upper lobe which slowly increased in size over a 3 year interval. Angiotensin I-converting enzyme and RR1023 loci were strongly linked to systolic and diastolic blood pressures in the male but not the female F2 progeny after salt loading for 7 months. This regimen may be considered an alternative, especially for patients with medical problems in which other regimens are contraindicated.

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These observations suggest that n-3 PUFAs decrease superoxide anion generation primarily by a prostaglandin-dependent pathway. We identified risk factors predicting unfavorable pathological outcomes after radical prostatectomy in patients with low risk prostate cancer. ludens captured in multilure traps baited with the synthetic white sapote blend was higher than the flies captured by the multilure unbaited traps (control) in field cages. Cigarette smoking has adverse effects on health causing ischemic heart disease, stroke, chronic obstructive lung disease and cancers of the respiratory and upper digestive tract, pancreas, kidney and urinary tract. Macrophage migration inhibitory factor in the human endometrium: expression and localization during the menstrual cycle and early pregnancy.

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The relationship between high thermo-stability of enzymes from hyperthermophiles and their low catalytic activity at room temperature is discussed. Among these four strains were the halophilic strains PH32, PH34 and GRP21, which did not grow in the absence of sodium chloride in culture medium.

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We found that, under conditions that stimulate vesicular glycine release, GLYT2 is rapidly trafficked first toward the plasma membrane and then internalized. Combination treatment that involves the association of colistin with classical anti-pseudomonal treatment has rarely been clinically tested. Indomethacin injury to the rat small intestine is dependent upon biliary secretion and is associated with overgrowth of enterococci. Endogenous substrates for protein carboxyl methyltransferase in cytosolic fractions of bovine brain.

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Child and family factors that predict diagnostic stability have the potential to guide treatment planning for children diagnosed with ADHD before 7 years of age. The keratometry values, axial length, anterior chamber depth, white-to-white (WTW) corneal diameter, and IOL power calculated using the Holladay 1 formula obtained with each device were recorded.

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When inhaled by humans it can replicate within alveolar macrophages and cause a severe pneumonia, Legionnaires disease. Quotations from Rudolf Virchow, on the occasion of the 50th anniversary of his death, September 5, 1952 The young offenders were not significantly different from the students in discounting the future, even though the young offenders scored significantly higher on a sensation-seeking personality scale, were less likely to have lived with their fathers, and had changed schools more often. After successful endoscopic sclerotherapy, an extrahepatic portal vein stenosis was diagnosed, and portal vein angioplasty was considered as primary therapeutic option. Interspecific comparisons did not show the predicted correlations between the strength of the response to DR and either reproductive life span, age of first reproduction, or total reproduction.

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Of the remaining 8 patients, GEM administration was terminated due to DLT on day 15, during the first course in 3 patients, while level 0 dosage reached MTD. Extensive cell lysis with pyknotic nuclear debris appeared at 48 hr postinfection, and cortico-medullary border was indistinguishable. Organizationally based CNSs function in a wide variety of management structures. Kinetics of iron oxidation by Leptospirillum ferriphilum dominated culture at pH below one.

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We found significantly lower transfusion rate, fewer patients with delayed graft functions, less vessel injuries, and less conversion to open surgical procedure with the retroperitoneoscopic approach than with the laparoscopic intraperitoneal approach. ESCS patients appear to have generally well-preserved cone- and melanopsin-mediated PLRs, indicating intact inner-retinal function. With the present small-scale study, we could not prove a positive effect of nicotinic acetylcholine receptor stimulation on osteoarthritis due to a conservative statistical analysis and the consecutive lack of significant differences.

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Pathology of post-kala-azar dermal leishmaniasis: a light microscopical, immunohistochemical, and ultrastructural study of skin lesions and draining lymph nodes. Four years after opening an all-volunteer free health clinic in Laramie, Wyoming, we interviewed community members and university faculty who were involved in the initial partnership. Although no other chemical procedures were employed to further characterize the extract, it may contain the estrogen binding protein isolated by others. Therefrom the osseous and disc changes associated with chronic torticollis may occur, as well as dolotren gel prospectors distant instabilities. Protein-protein interactions between terminal docking domains of successive multienzymes promote their correct positioning within the assembly line, but because the overall complex is not stable in vitro, the key interactions have not been identified.

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Studies using genetic- and epilim liquid emcor diet-induced animal models of HHcy have now demonstrated a direct causal relationship between HHcy, endothelial dysfunction and accelerated atherosclerosis. Isolated paratracheal mass of tuberculous origin in an adult patient. Glutamate is a neurotransmitter in the central nervous system, and the mechanisms of its release, signal transduction, and cellular reabsorption in the synaptic cleft are well understood.

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Lysates from the Jurkat T lymphocyte cell line were immunoblotted with anti-Pyk2, and two major forms raniplex 75 effervescent synonyms of Pyk2 were identified. It was shown that the addition of certain carbohydrates reduced the infectivity of Chlamydia psittaci in cell culture. Lymphocytes binding C-reactive protein during acute rheumatic fever.

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The complicated structures of the teva venlafaxine xr 75mg reviews for zootopia triple-pore COFs have been confirmed by powder X-ray diffraction and pore size distribution analyses. Considerable reduction in fecundity and fertility of adults was obtained. This article reviews results from ongoing SIP research in plant-microbe interactions, with a specific focus on investigating the fate of fresh and recalcitrant carbon in the rhizosphere with 13C enriched-root exudates, in addition to identifying key players in carbon cycling.

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Changes in histone modifications at floral repressor loci are stably maintained after cold exposure, establishing the competence to flower the following spring. Synchronous transitional cell carcinoma mittoval 10 mg compresse and metastatic hepatocellular carcinoma in the urinary bladder: a case report. Enhancing Spatial Memory: Anxiolytic and Antidepressant Effects of Tapinanthus dodoneifolius (DC) Danser in Mice.

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Butaprost, an EP(2) agonist, was effective only in the cells treated with LPS for 6 h. The presence of multimeric (polymeric and monomeric) IgA immune complexes (IC), detected by Raji cell assay and by the inhibition binding assay, as well as the specific metronidazole dosage chart for cats polymeric IgA-IC were examined before and after the ingestion of 100 g protein. Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation. Deoxynivalenol inhibits proliferation and induces apoptosis in human umbilical vein endothelial cells.

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The meetings included representation from the ADA, the American Dental Education Association, the American Student Dental Association, the ofelia vass uk top National Institute of Dental and Craniofacial Research and ADA-recognized dental specialty organizations. Brown recluse spider bites frequently induce necrotic, slowly healing lesions. Changes in the proportion and volume of care provided to children by generalists and subspecialists. A steady accumulation of experimental data argues that protein synthesis in neurons is not merely restricted to the somatic compartment, but also occurs in several discrete cellular micro-domains. In particular, we looked for ECM-mediated interactions, known to affect T cell migration.