Cyclophosphamide injection is also sometimes used to treat a certain type of lung cancer (small cell lung cancer; SCLC). It is also used to treat rhabdomyosarcoma (a type of cancer of the muscles) and Ewing's sarcoma (a type of bone cancer) in children. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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In the present study, in order to investigate the mechanisms of hyper-lipidemic acute pancreatitis (HLP), we established an animal model using lipoprotein lipase (LPL)-deficient heterozygous mice injected with caerulein. Interferon is an autosecreted cytokine that might be responsible for self-control of overgrowth of cells in wounds. Thus, Hilbert differential contrast phase electron microscopy of vitrified cells is a nano-scale molecular imaging technique that opens up new vistas for exploring the supramolecular organization of the mammalian cell.

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Rapid infusion system for neurosurgical treatment of massive intraoperative hemorrhage. A 29-year-old woman had lupus profundus since 1999, initially associated with thrombopenia (28,000 platelets/mm3) treated with corticosteroids for 6 months. Specific therapy consists of administration of diphosphonates, but its effectiveness has been a matter of controversy. Wound healing modulation by a latex protein-containing polyvinyl alcohol biomembrane.

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Arabidopsis MSI1 is needed for the correct expression of the floral integrator gene SUPPRESSOR OF CO 1 (SOC1). Subacute bacterial endocarditis in middle and later life with report of two cases. Through simulation it is shown that its performance compares favorably with that of the marginal independence approach.

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The dissolution profiles of four commercial quinidine sulfate tablets were determined using the USP rotating-basked dissolution apparatus. Confluent cells exhibited typical strong PECAM-1 expression at cell-cell borders. The BRAF V599E mutation was not found to be a major mutation in pancreatic cancers that had no K-ras codon 12 mutation. Offspring fathered by the PM- and DES-treated males exhibited neither malformations nor change of body weight gains, and the reproductive organ weights of 50-d old pups were in the normal range. Reflex receptive fields for human withdrawal reflexes elicited by non-painful and painful electrical stimulation of the foot sole.

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Exchange transfusion given 29 hours after birth in therapy of a congenital hemolytic disease Taken together, these advances in tumour imaging are set to have a profound impact on our basic understanding of in vivo tumour biology and will radically alter the application of mouse tumour models in the laboratory. The fructose analogue, 2,5-anhydro-D-mannitol (2,5-AM), triggers feeding in rats via a mechanism linked to its ability to trap phosphate and deplete hepatic ATP. A phaeochromocytoma-derived cell line, PC12, and two fibroblast cell lines, R208F and R208N.8, were encapsulated in sodium alginate microcapsules, crosslinked chitosan microcapsules and 60:40 acrylonitrile-vinylchloride copolymer (PAN/PVC) macrocapsules containing precipitated chitosan as an internal matrix.

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On 1 of the days a 5-h registration was performed after an overnight fast. Such lesions have been treated conservatively because of risk of restenosis but now are being considered for PCI to prevent plaque instability.

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On admission, he was febrile, toxic looking, dehydrated with hypotension and tachycardia. Our results perhaps lack significance probably because of lack of statistical power and do not distinguish costs related or not to chronic cervical pain. To our knowledge, this study is the first clinical trial to assess the effects of a web-based therapeutic program for drug users in Japan.

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Recovery of thresholds from 1-28 days after exposure was approximately exponential, and slowest at the edges of the exposure band. In addition to chemokines and pro-inflammatory cytokines, the early response genes included components of the Toll-like receptor signalling, antigen presentation and apoptotic pathways, interferon response genes, cell surface receptors and their ligands, including TNF-related apoptosis inducing ligand (TRAIL) and CD40, and other novel genes.

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First we analyzed which wound and patient attributes play a predominant role in the wound healing process and investigated a possibility to predict the wound healing rate at the beginning of the treatment based on the initial wound, patient and treatment attributes. To elucidate the role of epigenetic reprogramming in cell- or tissue-specific differentiation, we explored the role of DNA methyltransferases (Dnmts) in the nerve growth factor (NGF)-induced differentiation of PC12 (pheochromocytoma) cells into neuronal cells. Indirect immunofluorescence study using normal human skin as a substrate showed intercellular antibodies directed to the cell surface of the whole epidermis with a titer of 1:40. Acini exhibit a typical sponge-like pattern of irregular and empty cavities. Calcite crystal growth rates measured in the presence of several polycarboxyclic acids show that tetrahydrofurantetracarboxylic acid (THFTCA) and cyclopentanetetracarboxylic acid (CPTCA) are effective growth rate inhibitors at low solution concentrations (0.01 to 1 mg/L).

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Bladder neck closure may be beneficial in patients with refractory urinary incontinence secondary to outlet deficiency. Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. To evaluate the long-term stability of the marginal bone levels, gingival levels, and the status of the teeth, which underwent endodontic therapy, followed by CLP and final restorations.

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Three-dimensional changes in upper airways of patients with obstructive sleep apnea following maxillomandibular advancement. TNF-alpha, IL-6 and their soluble receptor serum levels and secretion by neutrophils in cancer patients. Iv administered 500 microg and icv administered alpha-helical CRH reversed the reduced NKCA and the elevated pituitary betaEP, while iv administration of 100 microg alpha-helical CRH did not. We show that in VHL-deficient cells p22phox, Nox4 protein levels and NADPH-dependent superoxide generation are increased.

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In the first case it occurred in a healthy individual and presented as a space occupying lesion mimicking a tuberculous granuloma. The hexahistidine-tagged LOX-1 molecule was purified by affinity chromatography from solubilized inclusion bodies. In vivo correlation between liver and blood energy status as evidenced by chronic treatment of carbon tetrachloride and adenosine to rats.

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Heritability of bipolar EEG spectra in a large sib-pair population. The European Confederation of Medical Mycology (ECMM) survey of candidaemia in Italy: antifungal susceptibility patterns of 261 non-albicans Candida isolates from blood.

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Functional assessment of the descending aorta flow is the most reliable method for differentiation of praeclamptic and eclamptic pregnancies with suspected fetal starvation and intrauterine growth retardation. Although diffuse demyelination can be induced in rats by rapid fluctuation of serum electrolytes, no studies have experimentally induced central pontine myelinolysis nor has it been observed incidentally in animals previously. To demonstrate the applicability of the proposed model a patient-specific carotid artery geometry is reconstructed and simulated in a finite element framework, providing a microstructural description of the arterial wall. This article provides an overview of the history, philosophy, and services components of psychiatric rehabilitation and analyzes its compatibility with social work.

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Efforts to minimize the neonatal false-positive hearing screen rates and to educate mothers about hearing screening are indicated to minimize unnecessary worry. This was not the case for either fundus examination or fluorescein angiography. To investigate the role of Hsp70 molecular chaperones in chloroplast protein import, we analyzed the import into pea chloroplasts of preproteins with decreased Hsp70 binding affinity in their transit peptides. Two well-characterized T4 origins, ori(uvsY) and ori(34), are believed to initiate replication through an R-loop mechanism. We tested whether female and male rats with left ventricular hypertrophy present the same susceptibility to demand ischemia.

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The preferential adhesiveness of BEL cells on fibronectin vs laminin was confirmed by attachment experiments performed on replicas of SDS-PAGE of these proteins. A total of 54 hypertensive patients received either 125 ml of a milk drink supplemented with whey peptides every morning or a control product for 12 weeks after a run-in period of 2 weeks. This study undertook extraction and identification of ricin, a toxalbumine, from Iranian Ricinus communis L. Different scaffold proteins play distinct roles in various signaling pathways by recruiting different downstream molecules. It is suggested that the SC can utilize cues from a variety of modalities in order to facilitate appropriate orientation behavior.

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It is most common in adolescence and seems often to be precipitated by stress. However, they are also highly vulnerable under various physiological and nonphysiological stresses because of their delicate act on breaking and rejoining DNA. In patients with adequate lymph node dissection, LNR staging does not add substantial information to the predictions of updated TNM lymph node staging. Peritoneal implants without ascites: preoperative CT diagnosis in colon carcinoma patients. Canine parvovirus (CPV), a model virus for the study of parvoviral entry, enters host cells by receptor-mediated endocytosis, escapes from endosomal vesicles to the cytosol, and then replicates in the nucleus.

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This was accompanied by the formation of supernumerary adaxonal Schwann cell processes which further altered the normal myelinating cell--axon relationship. Most cephalosporin antibiotics are excreted into urine via glomerular filtration and active tubular secretion by renal organic anion transporters. ANA-negative patients, who appear to have a relatively benign clinical course, should perhaps be treated with ursodeoxycholic acid alone. In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus.

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Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study. Executive functioning might have more effect on function than does memory. It is concluded that trisynaptic cortico-motoneuronal inhibition is evoked by consecutive activation of propriospinal neurones in C3--C4 and segmental Ia inhibitory interneurones. A study of the risk factor profile of cardiovascular diseases in rural Punjabi male patients.

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This article provides an overview of schizophrenia from the broad viewpoint of neuropsychiatry. The study of the influence of sialic acid receptors on virus infection may contribute to a better understanding of the cross-species transmission of the avian influenza virus. In the present study we tested the hypothesis that the facilitation of maternal behavior produced by amygdala lesions is mediated through the medial preoptic area.

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However, they are sources of atmospheric carbon when they are disturbed by human or natural causes. The kinetics of reduction of AFB(1) to B(2) and AFG(1) to G(2) by vitamin A has been investigated in dilute aqueous solution at 37 degrees C. Induction of erythroid differentiation in Friend leukemia cells by bromodeoxyuridine. Diagnosis of internal abscesses by scintigraphy: results of a method using purified granulocytes Intravitreal neovascular diseases are a major cause of blindness worldwide.

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The type of marital relationships of 200 women was significantly associated with the attitudes toward child-bearing and their affective reactions, as measured by the application of twelve content analysis scales to their retrospective accounts of a child-bearing year. Evaluation of background soil and air polychlorinated biphenyl (PCB) concentrations on a hill at the outskirts of a metropolitan city. To achieve this objective, the vast majority of states include measures of age, income, and race in their IFFs. Sixty-seven pregnant women with blood lead level ranging from 1.5 micromol/L to 4.8 micromol/L were randomly selected from the Department of Obstetrics of Qingdao Municipal Hospital between Mar 2005 and Mar 2006.

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Issues and problems identified include: complex scoring algorithms, inter-rater reliability of the BCCs, limited variability of WIB values, associations between resident characteristics and DCM assessments, rater time burden, and comparability of results across study settings. All the patients felt sudden pain at the moment of injury, all had a haemarthrosis, and yet the fracture escaped early diagnosis in one-third of the cases.

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Immunodeficient CD8 knockout mice were infected with Sarcocystis neurona merozoites, in order to determine the role of CD8 cells in protective immunity. Environmental sustainability: a target for environmental epidemiology? Is social participation associated with cardiovascular disease risk factors? The survey included perceptions of their actual disaster recovery involvement across 3 phases: days to weeks, weeks to months, and months to years. To compare sputa obtained by nasopharyngeal aspiration and by sputum induction for staining and culture of Mycobacterium tuberculosis.

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In vitro neuronal differentiation of cultured human embryonic germ cells. Early in vivo assessment of angiostatic therapy efficacy by molecular MRI. Data from the crystalline structure of homologous Escherichia coli PEP carboxykinase suggest that Arg(333) may be involved in stabilization of enolpyruvate, a postulated reaction intermediate. The measure the authors have developed calculates a weighted transcription agreement value based on principles derived from widely accepted tenets of phonological theory.

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The baseline values in the two total colectomy specimens were 76 and 101, and the mean (range) after segmental colectomy was 21 (1-98). Alumina particle air abrasion has a significant degradative effect on the bi-axial flexure strength of the porcelain disc-shaped specimens. Regression of upper gastric cancer in mice by FHIT gene delivery. However, in depressed patients there is no relationship between BMI and the persistence of depression.

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Expression microarray profiling showed that a significantly higher number of genes were regulated by LDL-delivered than albumin-delivered n-3 FA with little overlap between the two sets of genes. It is remarkable that low-complexity regions have the same form of distribution in proteins as in randomized sequences, and that the signal from randomized sequences with conserved local correlations and amino acid composition almost matches the signal from proteins. The molecular mass of recombinant glutaminase A (M(r) 106.8 kDa) and the molecular mass of the subunits (M(r) 26.9 kDa) were estimated by mass spectrometry.

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The hippocampus is required for the formation of declarative memories, while a number of other brain regions including the striatum, amygdala and nucleus accumbens are involved in the formation of nondeclarative memories. Observations from the present study indicate that early neonatal and pubertal development in male pigs are associated with elevated serum estrogen concentrations. Magnetic resonance imaging seems to be most suitable for evaluating the clinical condition and long-term follow-up of ARDEM.

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No detectable Chlamydia pneumoniae and cytomegalovirus DNA in leukocytes in subjects with echolucent and echogenic carotid artery plaques. An electromyographic study of the temporalis and masseter muscles. This will allow researchers interested in using facial stimuli access to a wider age range of adult faces than has previously been available. A great advantage of such recombinant antibodies is the possibility to functionalize them by introducing new amino acid sequences.

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Little expression of the activation markers E-selectin, ICAM-1, and VCAM-1 was observed by RT-PCR of endothelial cells growing on PES. Congenital polycythemias may result from inherited defects in hypoxia sensing, from inherited intrinsic defects in red blood cell precursors, or from inherited conditions that cause low tissue oxygen tension and secondary polycythemia.

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On the development of colloidal nanoparticles towards multifunctional structures and their possible use for biological applications. A novel technology: microfluidic devices for microbubble ultrasound contrast agent generation. A case is described of a woman with acute hepatitis C infection whose partner had chronic hepatitis C infection and where heterosexual contact was the only major risk factor. Then from the selected bands, it extracts the linear discriminative features by an improved Fisherface method and performs the classification by the nearest neighbor classifier.

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The key role of tubulointerstitium remodeling in progression of chronic renal diseases Afatinib showed some activity in NSCLC with acquired resistance to EGFR TKIs, although, currently, its efficacy after the failure of erlotinib or gefitinib has not been clearly stated. Photoperiod and melatonin affect testicular growth in the marsh rice rat (Oryzomys palustris).

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So, in our opinion, subclinical hyperthyroidism, far from being considered a simple laboratory finding, in clinical practice should be taken into serious consideration. Liposomes have recently emerged as rational vehicles for drug detoxification. When exposed to hydrogen peroxide to induce cell stress, Ex5 neonatal cardiomyocytes displayed a rapid collapse of mitochondria membrane potential, distinct from wild-type cardiomyocytes.

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Sixty-four fMRI studies investigating neural activity during visual emotive information processing in MDD were included. Extending the capabilities of targeted molecular dynamics: simulation of a large conformational transition in plasminogen activator inhibitor 1. A 13-year-old local girl presented to the emergency department with a 12-h history of lower abdominal pain and inability to pass urine. Of the 12 dog sera tested, four had a elevated IgM activity and three were considered to be false positive.

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Protective and therapeutic properties of the ubiquinones H6CoQ4 and CoQ9 in gamma irradiation Detection of drift effects before calculating the standard deviation as a measure of analytical imprecision. Statistical analysis of CT brain scans in the evaluation of cerebral atrophy and hydrocephalus. Minocycline and its analogues were tested in primary retinal cell culture to see whether they would inhibit light or oxidative stress-induced cell death. Methods are discussed for reducing and retarding edema, which expedites healing.

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All 69 GT 1a-infected patients who experienced viral breakthrough on treatment or relapsed during follow-up (relapsers) developed NS3 R155K. Therapy of cicatricial stenoses of the common duct by hepatico-jejunostomy in Y form While the validity of the identified exposure-specific miRNA profiles remains to be established, the findings thus far do raise interesting questions worth addressing in future studies. In this review, we provide a comprehensive summary of both indirect and direct AMPK activators and their modes of action in relation to the structure of AMPK.

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We present the case of a 27 year old woman with acute bilateral loss of vision associated with abdominalgia, bloody diarrhea and arthralgia. Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Long-term sensitization to the behavioral effects of naltrexone is associated with regionally specific changes in the number of mu and delta opioid receptors in rat brain. In order to eliminate plasma interference sepharose-beads with covalently coupled secretin antibodies are used to produce secretin-free standard plasma samples.

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Also, the rare GG genotype of rs726281 appears to influence migraine susceptibility in a recessive manner in MRM subgroup of female patients. Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study. This requires considerable amounts of time and a high level of operator skill. Multifactor analysis in prediction of outcome for ischemic stroke with combined cardiac symptomatology Prospective study of risk factors for development of non-insulin dependent diabetes in middle aged British men.

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Our data provide rationale for combining vascular endothelial growth factor-targeting therapy with ADT in hormone-sensitive prostate cancer. Since different slope values were obtained for different formulations of the same compound, the values reflected the release rates of the esters from the formulations.

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Criteria for the diagnosis include evidence of a recent tuberculous infection, demonstration of tuberculosis in the liver with or without local lymph node involvement and absence of older tuberculous lesions elsewhere. The dynamical and folding characteristics from circular dichroism, fluorescence, and backbone dynamics studies revealed that both wild type and mutant proteins showed distinct dynamical as well as stability differences, suggesting the important role of mutated residues in the sweet taste of SCM. According to thermal data from differential scanning calorimetry (DSC), discogen , which has the shortest hexyl peripheries, exhibited two LC phases, and and , with decyl and tetradecyl peripheries, respectively, displayed three LC phases as a function of the temperature.