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Clomipramine is a psychotropic agent used to treat obsessive-compulsive disorder (OCD). Clomipramine shares structural similarities with a class of antidepressants known as tricyclic antidepressants (TCAs). The exact mechanism by which Clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, Clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by blocking their reuptake and prolonging their activity. Clomipramine also has anticholinergic properties which means it blocks the action of another neurotransmitter, acetylcholine. This increases the risk for certain side effects. It also has weak antihistamine properties which appear to play a role in the mild sedative effects observed with use. Clomipramine was approved by the US FDA for the treatment of OCD in 1991.

Other names for this medication:
Clomipramine, Anafranil, Clofranil, Clomipramina, Clora, Zenil,

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Clomipramine comes as a capsule to take by mouth. At the beginning of treatment, clomipramine is usually taken three times a day with meals as the body adjusts to the medication. After several weeks of treatment, clomipramine is usually taken once a day at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clomipramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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Ethical issues in the managed care setting: a new curriculum for primary care physicians. The implementation of theory-based nursing practice: laying the groundwork for total quality management within a nursing department. Steady state kinetic studies on the reaction between esterase E-II from the venom of Bitis gabonica and the fluorogenic substrates, N-alpha-benzoyl-L-phenylalanyl-L-valyl-L-arginine-4-methylcoumaryl-7-amide and N-alpha-benzoyl-L-arginine-4-methylcoumaryl-7-amide were found to deviate from Michaelis-Menten kinetics. The effects of carvedilol on ischemia-reperfusion injury in the rat testis.

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An adult cuticle protein gene (Dacp-1) from Drosophila melanogaster has been isolated and characterized. (3) ICCs in non-diabetic mice proliferated abnormally and infiltrated into renal parenchyma with many cell structures formed. Phenotyping: personal contribution to research on increased susceptibility of individual HLA phenotype combinations in predisposition to contact allergies Biodegradable nonionic Tween series surfactants were employed to assess the effects of synthetic surfactants on the bioavailability of a target polycyclic aromatic hydrocarbon (PAH), phenanthrene, in soil/sediment-free micellar solutions.

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The formation of EG and OD are used to model oxidized graphene (OG). A higher proportion of females had a diagnosis of personality disorder. Method validation in relation to accuracy and precision for the gas chromatography-mass spectrometric analysis of 19-nortestosterone in urine with heptafluorobutyric anhydride and N-methyl-N-(trimethylsilyl)trifluoroacetamide. Stress status of gudgeon (Gobio gobio) from rivers in Switzerland with and without input of sewage treatment plant effluent. According to the adopted inclusion criteria, 20 studies were included and appraised.

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Wound healing activity of the ethanol root extract and polyphenolic rich fraction from Potentilla fulgens. Engineering cyanogen synthesis and turnover in cassava (Manihot esculenta). Where do patients known to a community palliative care service die? Insertion of this Arg in an important flexible loop showed changes of the bioluminescence color and the luciferase reaction took place with relatively retention of its basic kinetic properties such as Km and relative activity. In vitro eye-blink classical conditioning is NMDA receptor dependent and involves redistribution of AMPA receptor subunit GluR4.

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Prognostic value of in vitro bone marrow culture in refractory anaemia with excess of myeloblasts. The survivability of the heat-resistant (HR) variant cells at elevated temperatures of 43 degrees C for 160 min and 45 degrees C for 40 min was 2-4 logs greater than that of their respective parents.

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A 57-year-old female patient with cervical squamous cell carcinoma FIGO stage IIIB received pelvic irradiation for her disease. Destruction of hepatic secondaries without recourse to surgery has obvious advantages in severely ill patients. The practicability of this method was verified with three different transgenes: Cytosin Deaminase (AdCD), p53 (Adp53) and Granulocyte Macrophage Colony Stimulating Factor (AdGM-CSF). A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients. Appropriate tests indicated that she had visceral leishmaniasis (kala-azar).

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Young adult C57BL/6 wild-type or EAAC1 (-/-) mice were subjected to a controlled cortical impact model for TBI. In this work we presented the development of the unique CCHFV detection system fully based on reverse transcription--nested two-step polymerase chain reaction (RT-PCR). Characterization of human amnion epithelial and mesenchymal cells identified the most potent proliferation-inducing medium yet. (2) To understand the importance of considering environmental noise in clinical speech intelligibility testing.

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Molecular phylogeography reveals island colonization history and diversification of western Indian Ocean sunbirds (Nectarinia: Nectariniidae). A contact eatometer for automated continuous recording of feeding behavior in rats. Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways.

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Single-cell atlases require molecular signatures from many cells at a throughput afforded by mass cytometry-based, microfluidic-based, and microencapsulation-based methods. To observe the protective effects of follicle stimulating hormone (FSH) on human epithelial ovarian cancer cell apoptosis induced by cisplatin (DDP). Past and future use of the ICF (former ICIDH) by nursing and allied health professionals. Hepatic resection may afford little benefit for patients with liver metastases from pancretobiliary cancers.

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Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase. In vivo imaging of human pancreatic microcirculation and pancreatic tissue injury in clinical pancreas transplantation. To (a) identify patient characteristics that predict acceptance of guideline recommendations to add ACEI/ARB medications to diabetic treatment via MTM services and (b) examine how well different case characteristics (i.e., patient age and sex, type and number of recommendation attempts, type of health care plan) predict the odds of adding ACEI/ARB medications to diabetic regimens when recommended through an MTM call center. Interleukin-10 (IL-10) is a pleiotropic cytokine which increases bcl-2 levels and protects cells from steroid or doxorubicin-induced apoptosis. The aim of this work was to evaluate the impact of educational activities for rural and urban students to promote the use of sunscreens and prevent skin cancer.

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Fibin, a novel secreted lateral plate mesoderm signal, is essential for pectoral fin bud initiation in zebrafish. Aortic valve sclerosis relates to cardiovascular events in patients with hypertension (a LIFE substudy). Leptospira infection was asymptomatic using each inoculation route, and caused similar antibody production regardless of renal colonization. The little that exists suggests that atypical sexual interests are more common in men than in women, but the reasons for this difference are unknown. This study describes the management of MTBI patients in various European hospitals.

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Surgical site infection (SSI) after colorectal surgery is a frequent complication associated with substantial morbidity. Transgenic rabbits expressing human genes have been used as a model for cardiovascular disease, AIDS, and cancer research. The results made it possible to show that the 15 psychotherapeutic change process are embodied in the modes of vocal expression of their participants, and that the way in which these different modes are coordinated within the interaction makes it possible to observe regulatory micro-sequences that participate in the therapeutic change process. The disease is endemic in different parts ibufen tablets sale of the world and vaccination is the only way to protect pigs from CSFV infection.

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